60 min after tracer administration, the mice were sacrificed by cervical dislocation, and tissue and organ samples were collected for biodistribution analysis. This was done, because the in vivo PET data provide information on the local tracer intensity (individual voxel values) and the area of ...
Cells undergoing apoptosis were identified both in the dark and light zones, but more than half of these cells were located in the basal light zone. This is consistent with the concept that the progeny of cells which undergo somatic mutation in their immunoglobulin variable region genes in the ...
To achieve automated quantification of visceral adipose tissue (VAT) distribution in CT images and screen out parameters with discriminative value for inflammatory bowel disease (IBD) subtypes. This retrospective multicenter study included Crohn’s disea
Meanwhile it hardens, so that instead of being resilient it moves as a whole when palpated ; its rim becomes free from the surrounding host tissue, to which it had earlier united ; the surface epithelium weakens and becomes wet and pasty, instead, of firm, shiny and dry, and may be ...
Here we hypothesized distinct molecular circuits of microRNA/LD-associated target genes and searched for mechanistically linked serum and tissue biomarkers that would distinguish between DIS and human NAFLD of different grades. We analysed >800 rat hepatic whole genome data for 17 steatotic drugs and...
cellsor pathogens compromise healthy tissue. The innate immune system is not only the body's first line of defense, it is also present at birth. And because it always responds with the same relative force regardless of the abnormality, it is sometimes called the nonspecific immune system. ...
In a minority of patients, there is evidence that ongoing cytokine production develops, associated with persistent systemic inflammation, end-organ damage, and often death (Del Valle et al., 2020; Lucas et al., 2020). The relationship between the initial immune response to SARS-CoV-2, viral ...
Metrnl, a newly discovered adipokine with significant expression in white adipose tissue, promotes energy expenditure and contributes to the development of
The abnormal extracellular matrix accumulates with the lung tissue and vascular system are repeatedly micro-damaged, and the alveolar structure is destroyed, resulting in a decrease in the lung tissue's ability to exchange gas with the outside2–4. The clinical manifestations are cough and ...
This is defined by IASP as "pain that arises from altered noci- ception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain" [10, 11, 16]. Patients may ...