Evolution as we currently observe it is predominantly the result of what we call the 'horizontal transfer of information'. This phenomenon consists in the transfer of genetic information between one type of organism and another. The independently pre-evolved information of different types of organisms...
In our view, the zebrafish GlyR gene expansion (Hirata et al., 2010) reflects strong selective pressure for effective escape responses in this organism that develops externally with minimal parental care. Taken together, our data suggest that knocking down zebrafish orthologs of human hyperekplexia ...
to direct the action of an organism1,2. As such, dysfunctions of the PFC are associated with many cognitive and neuropsychiatric disorders3,4. In addition to regulating intellectual and emotional behaviors, PFC is even involved in modulating pain processing as well as the negative effect of pain...
A living organism must be studied from two distinct aspects. One of these is the causal-analytic aspect which is so fruitfully applicable to ontogeny. The other is the historical descriptive aspect which is unravelling lines of phylogeny with ever-increasing precision. Each of these aspects may ...
Type IV pili are flexible filaments on the surface of bacteria, consisting of a helical assembly of pilin proteins. They are involved in bacterial motility (twitching), surface adhesion, biofilm formation and DNA uptake (natural transformation). Here, we use cryo-electron microscopy and mass spect...
influencing factor or a stimulus (Hoonsopon and Puriwat, 2016; Yu et al., 2021) while the SOR framework suggests that involvement as a stimulus is likely to induce customer engagement including the feelings of identification, strong interaction, and even absorption as organism (Islam et al., ...
In food borne botulism and botulism by intestinal colonization such as infant botulism, which are the most frequent naturally acquired forms of botulism, the digestive tract is the main entry route of BoNTs into the organism. We previously showed that BoNT/B translocates through mouse intestinal ...
Once many of these connections are made, the brain employs a use-it or lose-it strategy; if the organism's subsequent experiences stimulate the synapse, it will strengthen and survive. If not, the synapse will weaken and eventually disappear. Researchers from Hiroki Taniguchi's lab at the ...
organism have impeded further exploration into the impact ofSegatellaon the gut ecosystem and host health. It is an obligate anaerobe with understudied nutritional preferences, and, despite the tremendous amount of genetic diversity reported within this clade1,3,10,11, until recently, there has ...
To perform these studies we use whole-organism RNA-seq since we and others have shown that this is a powerful method to define transcriptomic landscapes and identify genetic interactions18,19,20. Using this approach, we identified the molecular phenotypes of 53 homozygous mutant lines as well as...