planex–zorthogonal views, showing P62 immunolabeling in GFAP+astroglia and MAP2+neurons with DAPI+nuclei and quantification of P62+area overlaps with either GFAP+or MAP+territories. Data are expressed as the mean percentage ± s.e.m.;n = 7 independent ALI-COs per group; two-taile...
11). To further clarify the effects of IC-CeA and IC-NAc projectors on memory expression, we limited our optogenetic manipulations to the expression test period and found significant inhibitory effects on fear and extinction memory retrieval, respectively (Supplementary Fig. 12). Again, optogenetic ...
Nevertheless, because collected data on rock masses are usually very limited in number, and variable as well as imprecise in nature, investigation on such media is suffering from uncertainty. To take into account the uncertainties in data when carrying numerical models with the DEM and to analyse...
they are limited to simple readouts such as proliferation, averaged over all tissue cell types. The monitoring of genetically perturbed clones in normal epithelia and tumorigenesis requires scalable, tissue-wide platforms that can profile the transcriptomic consequences of gene perturbations across all cel...
Limited studies have addressed this question as detailed investigations into sphingoid backbones were only made possible by recent advances in lipidomics. Our group recently identified functional differences between d16:1 and d18:1 sphingosine 1-phosphates (S1P) in inflammatory signalling whereby d16:...
In addition, radiation therapy is limited or avoided in patients for whom the side effect burden is too high. In some cases, this is successful [7], suggesting a role for chemotherapy-only treatment for a subset of patients. There is therefore a need for strategies to identify patients ...
First, single-cell sequencing is limited in few patients, which prevents us to access comprehensive overview and broadly inspect myeloma pathogenesis and drug resistance. Further investigation in large-scale MM samples is necessary. Second, our present study discovered some interesting changes of both ...
Differential expression analysis was limited to cells from the sample sequenced at higher depth. Differentially expressed genes were identified by performing pair-wise and unique comparisons between the 3 clusters using DESeq2 (v. 3.4). Hierarchical clustering was performed using the union of the top...
This approach is not limited by the injection of recombinase-dependent viruses and therefore provides a platform for non-invasively controlling transgene expression in individual vagal and spinal afferent populations. However, one limitation of this approach is that a proportion of sensory neurons lacks ...
Stored on any one or on a combination of computer readable media is software for controlling both the hardware of the computer and for enabling the computer to interact with other elements, to perform the functions described above. Such software may include, but is not limited to, user ...