During a hydraulic fracture treatment, the magnitudes of the minimum principal stresses (in situ stresses) in the different layers of rock become a major factor in the growth of the fracture. The horizontal stress in the producing zone as well as the horizontal stresses in the surrounding ...
In successive eons of time the various kinds of animals leave their remains in the rocks which compose the deeper layers of the earth, and when the rocks are laid bare by wind, frost, and storm we find wondrous lines of ascent invariably following the principles of creative evolution, ...
In this study, a numerical technique combing a bonded particle model with a smooth-joint model (SJM) is proposed to represent the weak layers in inherently anisotropic rocks. The influence of the dip angle and spacing on strength and deformation of the jointed rock mass is examined in detail....
The geographic distribution ranges of species may vary dramatically, even among clades with close relationships [1,2,3,4,5]. Indeed, in some cases, geographic barriers constitute the boundaries of a species’ distribution range, yet commonly, the limit is regarded as a spatial expression of ecol...
increased in mTBI (Fig.7c and d), due to high density of astrocyte soma in the superficial layer we were unable to quantify Gfap mRNA in GFAP + soma. Immunostaining also showed that astrocytes in the Sp5C have a distinct expression pattern as they transverse through deep layers of ...
In addition, dmPFC neurons in different cortical layers can achieve this, through opposite control of thalamic and striatal regions. mPFC projections show distinct activation during inhibitory control Previously, we showed that distinct prefrontal projection populations can guide inhibitory control. Next, ...
Transduced pools were selected with puromycin 4 days after transduction, cultured separately for 2 weeks to allow viral silencing to proceed and then plated as single cells in standard hESC conditions in the presence of ROCK inhibitor Y27632 (ref. 33) to allow clonal outgrowth. After 5 days ...
11,15,39,40 The G protein-dependent engagement mechanisms and signaling pathways of CELSRs remain unexplored despite their crucial roles in neurodevelopment, although a connection to the RhoA/ROCK (Rho-associated protein kinase) pathway via the planar cell polarity pathway has been illustrated.41 ...
In this publication, we focus on the limited duration of an unsustained (one-time "run-down") stratification, where a DD staircase could develop tem- porarily until the boundary conditions for the zone of the mixed layers had changed to a degree that the staircase pattern could not be ...
Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal maintenance and application of embryonic stem cells (ESCs). While the protein-protein interactions of core pluripotency factors have been identified in mouse ESCs, their interactome in human ESCs (hESCs) has not to ...