By focusing on oxaliplatin and irinotecan resistance in colorectal cancer, we unravel that evolutionarily distinct chemoresistance can share consensus vulnerabilities identified by 26 second-round CRISPR screens with druggable gene library. We further pinpoint PLK4 as a therapeutic target to overcome ...
650 Gene22 821 Joe22 Results: Building 010 has 2 people working in it Building 650 has 2 people working in it Building 821 has 1 person working in it Reply labraun says: I need help with this same problem, different data of course. Would love to know if this is possible. Thanks!
First, all gene expression was centered and scaled via a z score, and PCA was applied to the scaled matrix. To determine the number of principal components (PCs) to keep, we used the same method described before25,61. Briefly, the scaled matrix was randomly shuffled and PCA was performed...
TheABCA1gene was positively correlated in adaptation to tropical environments according to theFST, XP-EHH, θπ ratio, and genotype patterns (Fig. S9A–B). To investigate whether the expression of theABCA1gene was associated with the environmental origins of pig breeds, we analyzed gene expressi...
(Supplementary Table9). For the remaining loci, multiple candidate genes were found. To gain a deeper understanding of the biological implications of genome-wide significant loci, we conducted a functional gene-set enrichment analysis using mapped genes with the highest evidence (Supplementary Table10...
[55], and expression of gene products [56]. Cells originated from different tissues may require quite different substrate stiffness for optimal survival and growth [57]. On the other hand, cells living on a matrix can modify the mechanical properties of the matrix depending on the cellular and...
(C, D) Weighted score of the T-cell–inflamed GEP in SCLC revealed a higher score in samples from late survivors compared with those who suffered early deaths whereas SCLC-Y had the highest GEP score of all the SCLC subtypes. GEP, gene expression profile; ICB, immune checkpoint blockade; ...
With this in mind, it is remarkable that mutations in phosphoribosylpyrophosphate synthetase 1 (PRPS1), which is the most ubiquitously expressed gene of the three PRS genes, are compatible with life. Mutations described thus far in PRPS1 are all missense mutations that result in PRS-I super...
The most highly represented contigs in each age group (0.1% of transcript pool; 79, 111 and 107 contigs for 0–4, 8, and 12-16dpp, respectively) exhibited markedly different profiles of putative gene function. Among those in common to all three groups were housekeeping genes including numerou...
However, it has not been thoroughly investigated how these histone modifications modulate the status of TSCs and contribute to the differentiation of TSCs towards both STs and EVTs and the extent to which SEs and histone modifications collaboratively influence lineage-specific gene expression in ...