Here, we found that mice with global ablation of SplitCre-Aβ-LTMRs showed decreased sensitivity to gentle mechanical forces, increased mechanical nociception at baseline condition, and increased mechanical hyp
To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA Bind-N-Seq technologies, and show that TAF15 binds to ∼4,900 RNAs enriched for GGUA motifs in adult mouse brains. TAF15 and FUS exhibit similar binding patterns in introns,...
m is the number of rows and n is the number of columns in the block. fun— Function handle handle Function handle, specified as a handle. The function must accept a block_struct as input and return an array, vector, or scalar. If fun returns empty, then blockproc does not generate ...
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differentiation function single-cell RNA sequencing mass cytometry Introduction Langerhans cells (LCs) have diverse functions in skin homeostasis, inducing either immunogenic or tolerogenic responses (Kashem et al., 2017; Seneschal et al., 2012). While LCs have been associated with several inflammatory ...
Because activities regarding marketing-mix processes are usually associated with the marketing function [e.g., 83], knowledge assets such as quality data available in the marketing unit should play a prominent role. As Subramaniam and Youndt [84] point out, quality data involving up-to-date, ...
The AddModuleScore function in Seurat was used to define the scores of the genes of interest. Specifically, the AddModuleScore function calculated the average expression levels of each program (cluster) at the single-cell level, subtracted by the aggregated expression of the control feature sets....
Function redundancy, for instance among PIR genes, could be partially responsible for this result. Thus, we assayed the triple mutant Δpir1-3 in a different genetic background (S. cerevisiae RAY3A cells) [48] but did not observe a significant effect (Additional File 6), contrary to the ...
(Supplementary Fig.1a), which leads to inversional VK-JKrecombination23. Based on the known function of loop extrusion in controllingIghrecombination20,32, the reverse orientation of both the CBEs and VKgenes in theIgklocus appears to be incompatible with a role of extended loop extrusion in ...
Where, a and b represent an FSF and a proteome respectively; g ab describes the g value of the FSF a in the proteome b; g max is the maximum g value in the matrix; Round function normalizes the g ab value taking into account the g max and standardizes the values to a 0–23 scal...