human ileumluminal compositionCharacterize the contents of distal ileum and cecum in healthy adults under conditions simulating the bioavailability/bioequivelance studies of drug products in fasted and fed state. Twelve males participated in a two-phase crossover study. Phase I: subjects remained fasted...
and subsequently at days 7, 14, 21 and 27 during the feeding trial. On day 28, the piglets were sacrificed and host gut tissue and digesta samples taken from all intestinal regions (duodenum, jejunum, ileum, cecum, and colon) for down-stream analysis ...
Holman GD, Naftalin RJ, Simmons NL, Walker M: Electrophysiological and electron-microscopical correlations with fluid and electrolyte secretion in rabbit ileum. J Physiol 290:367–386, 1979 Rummel W: Biologische Membranfunktionen in Gesundheit und Krankheit. Wirkungen von Gallensuuren und Laxatien...
Vertzoni, Characterization of contents of distal ileum and cecum to which drugs/drug products are exposed dur- ing bioavailability/bioequivalence studies in healthy adults, Pharm. Res. 32 (2015) 3338-3349.Reppas, C.; Karatza, E.; Goumas, C.; Markopoulos, C.; Vertzoni, M. Characterization ...
DIOS, a common cause of abdominal pain in CF patients, is due to impaction of muco-feculent material in distal ileum and cecum. Conventional therapy with mucolytics, laxatives and retention enemas is often unsatisfactory and may require hospitalization. We have extensive experience with the use of...
It is characterized by an intestinal obstruction secondary to fecal impaction in distal ileum or cecum. We report two adult patients with DIOS. A female with CF and subjected to lung transplantation at the age of 13 years old. Five years later, she consulted for an intestinal obstruction. She...