This conclusion was supported by calculation of the contact surface areas taking part in the dissolution process for the systems tested. The procedure developed in this study could be applied to preformulation work where a cohesive, low solubility drug of hydrophobic nature is to be formulated....
Is Sink Condition as Classically Defined a Viable Parameter to Establish a Discriminative QC Dissolution Method for ASD Formulations — Considerations for Method Development Current regulatory guidelines do not address appropriately how to develop dissolution methods for product release testing in a quality ...
(2006). An improved model for the calculation of CO2 solubilites in aqueous solutions containing Na+ , K+ , Ca2+ , Mg2+ , Cl- and SO24− , Marine Chemistry, 98, 131-139. Egermann, P., Bazin, B., Vizika, O. (2005). An experimental investigation of reaction- transport ...
In general, efforts should be made to provide a gradual dissolution profile for at least one of the actives, with percent dissolved less than 85% at the 15-minute time point to allow for f2 calculation9. The method should provide complete dissolutio...
(See the supplementary information for the detailed calculation.) The activation energy was 65 and 92 kJ/mol for pure water and seawater, respectively, and the rate of decrease in the radius of the CsMPs was estimated to be 0.007 and 0.058 μm/y for pure water and seawater, respectively...
This change of variables gives an equation identical in form but scaled by the concentration difference (cs,i−c∞,i), leading to more convenient boundary conditions and a straightforward calculation of the Sherwood number. The transport of nitrogen and oxygen are modelled using separate scalar ...
Petralito S, Zanardi I, Memoli A, Annesini CM, Millucci V, Travagli V. Apparent solubility and dissolution profile at non - sink conditions as quality improvement tools. In: Basnet P, editor. Promising pharmaceuticals. Croatia: InTech; 2012. p. 83-100....
All “active” disintegrant cells mark their direct neighbors for random scattering within the calculation matrix. The labeling depth, i.e., radius around the active disintegrant particles, can be set through the simulations parameter (C2). All marked cells are randomly distributed in the surroundi...
2.2.2. Percentage Yield Calculation Percentage yield of fibers obtained from 5 gm of physical mixtures of different formulations (Table 1) of OXC with and without polymer was calculated using the following equation and calculation was considered as an important tool in selecting the best OXC/excipie...
Because of the Sieverts’ constant scattering, its calculation relied on Equation (7) to ensure the continuity of the chemical potential instead of the concentration. During the system transient, the aforementioned difference between BCs experienced by “wet” and “dry” steel surfaces implies that...