This conclusion was supported by calculation of the contact surface areas taking part in the dissolution process for the systems tested. The procedure developed in this study could be applied to preformulation work where a cohesive, low solubility drug of hydrophobic nature is to be formulated....
Is Sink Condition as Classically Defined a Viable Parameter to Establish a Discriminative QC Dissolution Method for ASD Formulations — Considerations for Method Development Current regulatory guidelines do not address appropriately how to develop dissolution methods for product release testing in a quality ...
5. The order of introduction of metal species into the oxide is stochastically predefined according to the alloy composition and remains fixed. This translates to no Ni-Cr exchange within the alloy. Physically, this condition corresponds to a dilute concentration of vacancies, dislocations, and void...
A theoretical framework has been proposed to account for the effects of rate and schedule of supersaturation on the MSZW calculation (34). Kinetically, when the supersaturating system moves away from equilibrium at a faster rate (i.e., higher rate of supersaturation generation in Fig. 7a) or...
(See the supplementary information for the detailed calculation.) The activation energy was 65 and 92 kJ/mol for pure water and seawater, respectively, and the rate of decrease in the radius of the CsMPs was estimated to be 0.007 and 0.058 μm/y for pure water and seawater, respectively...
The calculation process of the analytical solution is described in a previous work [42]. The maximum velocity at the center of the cross-section obtained from the simulation was 1.8707 × 10⁻⁸ m/s, while the average velocity was 1.2225 × 10⁻⁸ m/s. The analytical solution ...
Table 6. The F2 values calculation was based on the mean values of profiles in the particular formulation. Empty Cell Empty CellMeasured vsMeasured vsMeasured vs nominal regressionspectral regressionAAN prediction FormulationLevelsnTime (min)F2nTime (min)F2nTime (min)F2 FDF 1(1,1,1) 3 10 62...
Petralito S, Zanardi I, Memoli A, Annesini CM, Millucci V, Travagli V. Apparent solubility and dissolution profile at non - sink conditions as quality improvement tools. In: Basnet P, editor. Promising pharmaceuticals. Croatia: InTech; 2012. p. 83-100....
while the alloy and solution are treated implicitly as a cation source and sink, respectively. Metal atoms/cations are considered mobile species, and electrons are assumed to equilibrate adiabatically to maintain local charge balance. The applied potential is simulated by adjusting the relative energy ...
This change of variables gives an equation identical in form but scaled by the concentration difference (cs,i−c∞,i), leading to more convenient boundary conditions and a straightforward calculation of the Sherwood number. The transport of nitrogen and oxygen are modelled using separate scalar ...