3.6. Calculation domain and simulation parameters To simplify the unit transformation from lattice unit to physical unit, the dimensionless units are introduced. In this study, the characteristic parameters are defined in Table 1. In this way, the relative parameter equals to effective value over the...
Conclusion : The pharmaceutical industries that produce generic drugs must study the bioequivalence in vitro using calculation similarity and difference factors as quality tests. Also, studying the release mechanism is of important to ensure the in vitro bioequivalence based on mathematical models . ...
BET calculation method was applied for P/P0 where N2 adsorbed volume was found to be linear. For each material, a raw pellet was analyzed by dilatometry (Setaram SetSys Evolution) to follow its sintering during the thermal treatment at 1600 °C under reducing atmosphere (Ar – H2 4.5%)....
h to remove physically adsorbed moisture. Values of SSA were determined from BET isotherms. Calculation of particle size dBETwas done according to Eq.(1), where ρ— calculated density of diopside, 3.278 g/cm3[35], SSA — specific surface area and dBET— particle size.(1)dBET=6/ρ×SSA...
Since the compounds in the same BCS class have similar dissolution and absorption characteristics, in order to simplify the IVIVC calculation and dissolution evaluation, the individual dissolution profiles of the Q-markers within a class are integrated into a single dissolution profile based on their ...
The calculation of R takes into account the relationship between the dimensions of the segment and its cylindrical representation: Volume=π×R2×LVolume=π×R2×L (5) To estimate the parameters, a perfusion volume of 10 mL was employed for the entire small intestine. The length of the ...
were very similar. This was also confirmed by a calculation of the mean distance of the γ′-precipitates and the diffusion length of the dissolving γ′-forming elements Al and Nb within the Ni-matrix. Previous SANS measurements [26] showed that the mean size of the γ′-precipitates is ...
This effect was taken into account and mitigated by performing longer experiments, to reduce the overall weight of the first phase of the pressure decrease curves in the deviation calculation, and thus on the dissolution parameters estimates. In other words, this discrepancy did not meaningfully ...
start in the subsequent plastic deformation process. The orientation and densities are different in different plates along RD and TD, and the average value of µ(µ )(µ¯)can be calculated to reflect the mechanical behavior of the plates. In the process of calculation, only the main ...
Figure 7. Initial molecular structures in the calculation. (a) Phospholipid; (b) PPD. Figure 8. 3D conformation of PPD and phospholipid after docking and optimization. (a) PPD and phospholipid with interpolated charge surface; (b) H-bond interactions in the complex. 2.4. Equilibrium Solubili...