Transport rates observed in the presence of di- or tri-nucleotides (NDP or NTP), as compared to mononucleotides (NMP), suggest the requirement of at least two phosphate groups of the nucleotides to activate [α32P]ATP transport. On the other hand, UTP and UDP could act as suitable nucleot...
This peptide is It exerted anti-tumor activities ainVvHitCroDaRnd2 from mAb C7, in vivo against raised against Candida murine B16F10-Nex2 albicans antigens1,3. melanoma and was cytotoxic to human cancer cell lineages. Current clinical data attesting the efficiency of peptide-based cancer ...
Oxidative stress seems to activate NF-kB through the inhibition of HDAC activity and degradation of inhibitor of NF-kB (IkB)-a (refs 12,14,15). Pro-inflammatory gene expression is normally silenced by the condensation of DNA; however, the acetylation of core histones opens up the condensed ...
Moreover, the ability of TPE to upregulate the expression of intratumor Nrf2 and its nuclear translocation may lead to the induction of various antioxidant and detoxifying enzymes to limit DMBA-induced oxidative stress which is known to activate NF-κB. It is also likely that Nrf2 may directly ...
GVHD occurs when the host immune system is inhibited and donor T cells respond to host self-antigens, so it tends to develop after allogeneic hematopoietic stem cell transplantation [52]. Galectin-1, generally considered an immunosuppressive molecule, was demonstrated to improve survival after ...
cells (PBMCs) exposed to peptides derived from the HPV-16 capsid (HPV16(L1)). This could reflect an increase in the immune activity toward HPV-16. At the same time, some active substances reduced the lympho-proliferation and the expression of T-cell activation markers. Finally, some of ...
adolescentis isolated from the feces of elderly humans, indicating that the gut microbiota modified by these strains might alter the composition of bile acids and activate the bile-acid receptor TGR5. In addition, an HFD has been shown to significantly reduce the abundance of Faecalibaculum [12,...
All the B. adolescentis strains alleviated inflammations in the spleen and brain and modified the cecal and colonic microbiota. Particularly, all strains reversed the HFD-induced depletion of Bifidobacterium and reduced the development of beta- lactam resistance. In addition, the B. adolescentis ...