Little is known about obsessive-compulsive symptoms (OCS) in the context of chromosomal disorders involving the X chromosome. Methods Case studies of two patients with chromosomal disorders involving the X chromosome (Patient 1 with a variant of Turner syndrome and Patient 2 with triple X syndrome)...
Altered anatomic connection mainly involving the prefrontal cortex, hippocampus, and striatum in relatives may be related to illness risk. Gray matter network alterations in probands Network disorganization involving the superior and middle temporal cortex was observed in patients in comparison with their ...
This important study demonstrates APOE4-dependent activation of a pro-inflammatory signaling pathway in pericytes involving cyclophilin A–nuclear factor-kappa B–matrix metalloproteinase-9-mediated degradation of blood–brain barrier basement membrane and tight junction proteins. Article CAS PubMed PubMed ...
Treatment consists of administration of intravenous fluid when dehydration is suspected and correction of electrolyte imbalances involving sodium, potassium, phosphate, calcium, or magnesium metabolism as well as monitoring of core temperature (Santelli et al., 2014, Atha, 2013). Hyperthermia is a ...
59 While underconnectivity in ASC has been proposed primarily for higher-order association areas of the brain,60 our study suggests a possible extension of this concept to relatively lower-level perceptual systems involving subcortical regions. Geschwind59 has suggested that histogenic events that ...
[145,146]. For instance, changes in resting-state functional connectivity may be linked to abnormal self-body image perception in patients with anorexia nervosa. The functional connectivity of the auditory network is also diminished, mainly involving the precentral gyrus, postcentral gyrus, and insula...
Studies involving 31P-mag- netic resonance spectroscopy have reported decreased pro- duction of ATP elevated levels of lactate, reduced levels of carnitine [140,147-149], and other measures of mitochon- drial dysfunction [150,151]. Immune dysfunction, oxidative stress, and mitochondrial dysfunction...
Furthermore, major subcortical components of the LHPA axis (eg, hypothalamus, hippocampus, amygdala, and BNST) have also been identified as key components of anxiety/fear neurocircuitry (albeit sometimes involving different subnuclei, for example paraventricular nuclei vs ventromedial hypothalamus for L...
Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation. J. Clin. Endocrinol. Metab. 89, 936–942 (2004). Article CAS Google Scholar Rached, M., Buronfosse, A., Begeot, M...
The use of resveratrol in treating inflammatory diseases has been evaluated in many studies, including those involving rodents. The results of these studies contributed to broadening the knowledge about the pharmacology of resveratrol and its potential use [55,65]. Resveratrol has been shown to reduce...