Eligibility criteria for participation were: a confirmed ADHD-diagnosis (International statistical Classification of Disease 10th revision (ICD-10) or DSM-V), age 5–55 years, stable pharmacological treatment (no change during the last four weeks) and an ability to read Swedish (due to the ...
Genes & Immunity (2020) Conserved DNA Methylation Signatures in Early Maternal Separation and in Twins Discordant for CO2 Sensitivity Francesca Giannese Alessandra Luchetti Marco Battaglia Scientific Reports (2018) Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogen...
SERPINB2 participates in multiple cellular functions, including cell survival, cell differentiation, inflammation, immunity, cell adhesion, migration, and extracellular matrix remodeling in multiple disease states via its interactions with intra and extracellular proteins [49,50,51]. Despite extensive ...
In 1943, Leo Kanner of Johns Hopkins University published “Autistic disturbances of affect contact” in the special issue of the journalThe Nervous Child, which systemically examined 11 cases of autism and named it “early infantile autism”.1Kanner used the term ‘infantile autism’ to describe ...
All patients were carefully monitored for safety (e.g. suicidality, significant worsening) during course of the study. We recruited 24 age- and sex-matched healthy control Participants using the ICD-10 criteria to ensure that they had no previous or current psychiatric disorders. Table 1 describes...
CSMD1, which has also been associated with schizophrenia [51, 52], is a complement control-related gene, and supports the theory of diminished activity of immunity-related pathways in the brain as a disease mechanism for psychiatric disorders including BD [53]. CSMD1 protein can inhibit the ...
However, due to insufficiency of relevant data, a molecular picture of the immune system abnormalities in PTSD is yet unclear. The complement system is major effector of the immune response, which acts on the interface of innate and adaptive immunity, and is a key component and trigger of ...
including humoral and cellular immunity along with abnormalities at the molecular level, have been reported. There is evidence of altered immune function both in cerebrospinal fluid and peripheral blood. Several studies hypothesize a role for neuroinflammation in ASD and are supported by brain tissue an...
People with psychotic disorders show abnormalities in several organ systems in addition to the central nervous system (CNS); and this contributes to excess mortality. However, it is unclear how strong the evidence is for alterations in non-CNS systems at the onset of psychosis, how the alteration...
In this explorative study, we investigated if an adjunctive treatment with one single dose of the monoclonal antibody rituximab would improve symptoms and function in treatment-resistant patients with schizophrenia spectrum disorder (SSD, n = 9) or obsessive-compulsive disorder (OCD, n = 10), based...