An association between some alleles of human leukocyte antigens (HLA) and autoimmune diseases has been established. Several studies have revealed links between HLA and ASD, where autistic children were found to have a higher frequency of HLA-DRB1*11 allele and lower frequency of HLA-DRB1*03 alle...
SERPINB2 participates in multiple cellular functions, including cell survival, cell differentiation, inflammation, immunity, cell adhesion, migration, and extracellular matrix remodeling in multiple disease states via its interactions with intra and extracellular proteins [49,50,51]. Despite extensive ...
In contrast to WT mice, immunodeficient Rag1−/− mice did not exhibit reduced interest in exploring the central region and locomotion in the open-field test (OFT) (Figure 1B), implying that the adaptive immunity is required for the onset of anxiety. Consistent with previous reports (Dha...
Major depressive disorder (MDD) represents one of the most frequent and burdensome diseases on a global scale (Vos et al., 2016). In the course of the broad armamentarium of effective psychopharmacotherapeutic options, the choice of the first-line antidepressant (AD) agent is usually dependent...
(ICD)-9 or ICD-10 codes for DS, ASD, or well-child check visits for NT individuals. The first vitamin D 25-OH level recorded in the electronic medical record (EMR) was used in this study as it was felt to be the most reflective of a natural and non-supplemented state. Vitamin D ...
More remains to be learned regarding the regulation of inflammation in response to both acute and chronic stressors. Hundreds of genes or proteins are involved in immunity and inflammation regulation and should be studied in relation to psychiatric disorders. Only a limited number of them have been...
People with psychotic disorders show abnormalities in several organ systems in addition to the central nervous system (CNS); and this contributes to excess mortality. However, it is unclear how strong the evidence is for alterations in non-CNS systems at the onset of psychosis, how the alteration...
CSMD1, which has also been associated with schizophrenia [51, 52], is a complement control-related gene, and supports the theory of diminished activity of immunity-related pathways in the brain as a disease mechanism for psychiatric disorders including BD [53]. CSMD1 protein can inhibit the ...
Eligibility criteria for participation were: a confirmed ADHD-diagnosis (International statistical Classification of Disease 10th revision (ICD-10) or DSM-V), age 5–55 years, stable pharmacological treatment (no change during the last four weeks) and an ability to read Swedish (due to the ...
Immunity, inflammation, and bipolar disorder: diagnostic and therapeutic implications. Curr Psychiatry Rep. 2013;15:387. Article PubMed Google Scholar Hendrie HC, Lindgren D, Hay DP, Lane KA, Gao S, Purnell C, et al. Comorbidity profile and healthcare utilization in elderly patients with ...