Journal2012,Brain, Behavior, and Immunity CharityOnore, ...PaulAshwood 1Introduction Autismspectrum disorders (ASD) are a series ofpervasive development disorderswhich include autistic disorder, Rett’s disorder,childhood disintegrative disorder, Asperger’s syndrome orpervasive developmental disorder not ot...
These are a heterogeneous group of monogenic disorders characterized by life-threatening infections, autoimmunity, immune dysregulation, inflammation and/or malignancy which occur as a result of impairments in host immunity. From:Seminars in Hematology,2020 ...
Total DALYs per cause equal the sum of years of life lost to premature mortality and years lost to disability. The ICD-11 lists mixed episodes as a distinct episode-category; the DSM-V categorises them as variations of manic, hypomanic, and depressive episodes. Otherwise, the descriptions ...
These findings suggest the need to define a different biological function for these patients (with PTSD and current MDD) with singular alterations in the HPA axis, which likely influence other response mechanisms to stress, such as inflammation and immunity. It is warranted to analyse these results...
including humoral and cellular immunity along with abnormalities at the molecular level, have been reported. There is evidence of altered immune function both in cerebrospinal fluid and peripheral blood. Several studies hypothesize a role for neuroinflammation in ASD and are supported by brain tissue an...
SERPINB2 participates in multiple cellular functions, including cell survival, cell differentiation, inflammation, immunity, cell adhesion, migration, and extracellular matrix remodeling in multiple disease states via its interactions with intra and extracellular proteins [49,50,51]. Despite extensive ...
people gradually realized that autism is a developmental disorder under the influence of certain genetic factors.13,14On this foundation, substantial research into the genesis of autism has been conducted, including molecular genetics, neuroimmunity, functional imaging, neuroanatomy, and neurochemistry resea...
People with psychotic disorders show abnormalities in several organ systems in addition to the central nervous system (CNS); and this contributes to excess mortality. However, it is unclear how strong the evidence is for alterations in non-CNS systems at the onset of psychosis, how the alteration...
In contrast to WT mice, immunodeficient Rag1−/− mice did not exhibit reduced interest in exploring the central region and locomotion in the open-field test (OFT) (Figure 1B), implying that the adaptive immunity is required for the onset of anxiety. Consistent with previous reports (Dha...
Music affects health through changes in 1) reward, motivation, and pleasure; 2) stress and arousal; 3) immunity; and 4) social affiliation.4 Music interventions can improve depressive symptoms, sleep quality, global and social functioning in mental disorders. Music therapy can be classified as ...