Humans have cultivated Goldfish for centuries. Starting with a drab silver-gray fish, the Chinese and then the Japanese transformed it through centuries of selective breeding into what it is today. They now come in many colors, fin variations, body shapes, and eye types that rival the most ex...
A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence? Hum. Genet. 120, 779–788 (2007). Article CAS PubMed Google Scholar Tishkoff, S. A. et al. Convergent adaptation of human lactase persistence in Africa and Europe. Nat. Genet. 39, 31...
The presence of dyspnea or hemoptysis provides a starting point. Gas exchange is impaired by ongoing alveolar hemorrhage, and there is an increased need for transfusion in the perioperative period owing to the acute and chronic loss of red blood cells. It is prudent to postpone elective surgery ...
Patients who are the starting points of genetic studies in families. Pathogenic Variant that has an effect on protein function that is associated with a specific disease phenotype. Hypomorphic A mutation that results in reduced expression or reduced activity of a protein. The resulting disease phenoty...
Candidiasis, coccidioidomycosis, histoplasmosis, listeriosis, nocardiosis, and infections due to nontuberculous mycobacteria were reported with significantly greater frequency among infliximab-treated patients. Seventy-two percent of these infection occurred < or =90 days after starting infliximab treatment, and...
1 This rare genetic disorder is characterized by a progressive muscle breakdown, starting with those closest to the body’s core and moving to affect the extremities.2 Historically, the life expectancy of DMD carriers barely stretched beyond the teen years. New drug therapies,...
In 1958, Wagner and Lanoix developed a model of major transmission depicted in what has become known as the ‘F-diagram,’ based on steps within the fecal–oral flow of transmission starting with the letter ‘F’: fluids (drinking water), fingers, flies, fields (crops and soil), floods ...
We will expand to other disease areas by starting with other disease clusters and generating corresponding GBPN. We also propose to explore other clustering algorithms besides Louvain community detection for focused subgraph generation (e.g. Leiden [74] community detection), as each algorithm will ...
Seven twofold-by-twofold serial dilutions starting, with a tenfold dilution of blood sera were made on a 96-well plate. Human recombinant IL-6 was used as the standard and a calibration curve was prepared by making nine twofold-by-twofold serial dilutions starting with 5 units/ml. Cell ...
In this systematic review, we evaluated the temporal progression of clinical abnormalities experienced by patients who recovered from an infection with SARS-CoV-2, starting with a mean of 30 days post–acute illness and beyond. The results suggest that rates of PASC are indeed common; 5 of 10...