Dose response for starting and stopping HIV preexposure prophylaxis for men who have sex with men This study estimated the number of daily tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) doses required to achieve and maintain (after discontinuatio... SM Seifert,DV Glidden,AL Meditz,... -...
An iterative approach has been proposed, starting with a biological problem, developing a mathematical model, and then feeding back into the biology. Once established, this collaborative loop can be traversed many times, leading to ever increasing understanding. The ultimate goal of in silico ...
A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence? Hum. Genet. 120, 779–788 (2007). Article CAS PubMed Google Scholar Tishkoff, S. A. et al. Convergent adaptation of human lactase persistence in Africa and Europe. Nat. Genet. 39, 31...
We will expand to other disease areas by starting with other disease clusters and generating corresponding GBPN. We also propose to explore other clustering algorithms besides Louvain community detection for focused subgraph generation (e.g. Leiden [74] community detection), as each algorithm will ...
Thus, the rise of agriculture starting 11,000 years ago played multiple roles in the evolution of animal pathogens into human pathogens1,4,10. Those roles included both generation of the large human populations necessary for the evolu- tion and persistence of human crowd diseases, and generation...
Currently, women around the world are still suffering from various female common diseases with the high incidence, such as ovarian cancer, uterine fibroids and preeclampsia (PE), and some diseases are even with the high mortality rate. As a negative feedback regulator in G Protein-Coupled Recepto...
1 This rare genetic disorder is characterized by a progressive muscle breakdown, starting with those closest to the body’s core and moving to affect the extremities.2 Historically, the life expectancy of DMD carriers barely stretched beyond the teen years. New drug therapies, ...
For these analyses, COVID-19 convalescent plasma volume was stratified in 200 mL increments starting with a volume of less than or equal to 200 mL and ending with a volume of 1800 mL or more. Then, a breakpoint at 600 mL of COVID-19 convalescent plasma was tentatively posed, comparing ...
They play a significant role in various cellular pro- cesses such as membrane fusion, fission, endocytosis, protein trafficking, and protein functions. Interestingly, recent studies have revealed their more impactful and critical involvement in infectious diseases, starting with the manipulation of the ...
However, the starting point was selected from the two (2) first pregnant women. The main tool of data collection was a questionnaire that was reviewed and validated by the research team (principal investigator and coprincipal investigators). It comprises five major sections: demographics questions,...