Lesions of the cerebellum and brainstem may appear similar to demyelinating diseases such as multiple sclerosis [38]. ECD related suprasellar lesions should be considered in the differential diagnosis alongside Langerhans cell histiocytosis or other adenomatous, granulomatous or inflammatory processes of this...
In the aged mice (>15 months), the aged microglia and MDMs are unable to reach the lesions which contributes to the decline in remyelination and compromised uptake of myelin, resulting in the neurodegeneration diseases like multiple sclerosis30,132 and Alzheimer's disease32,133,134. Besides, ...
seamlessly integrates the two types of diseases, with OMIM and GWAS evidence alike. For instance, dedicated and up-to-date GWAS datasets from the GWAS Catalog (https://www.ebi.ac.uk/gwas/) can be used in a similar fashion to build the genotype-based layer of alternative multiplex disease ...
The induction of cancer may also be induced by disturbances in the prevalence/constitution of gut flora. Therefore, the prevalence of CRC is much higher in the large intestine than in the small intestine. This is attributed to the higher microbial population in the large intestine, especially the...
Riluzole, a treatment for amyotrophic lateral sclerosis (ALS), has been shown to be an effective pretreatment that sensitizes glioma to radiation therapy. It also has synergistic effects in combination with select other drugs when used to treat GBM. [62] Cannabidiol, another ALS treatment, ...
An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and whether consistent genetic relationships exist between MS and the two predo
Selective loss of myelin and OLs contributes to the pathogenesis of progressive neurodegenerative diseases such as multiple sclerosis (MS) (Trapp and Nave, 2008) and leukodystrophies (Knaap and Bugiani, 2017). Similarly, white matter degeneration and myelin loss have been observed in other ...
112 (64%) families with a history of multiple sclerosis reported autoimmune disorders (excluding multiple sclerosis) in one or more first-degree relatives, whereas 64 (36%) families reported no history of autoimmunity. Similar to index cases, Hashimoto thyroiditis, psoriasis, and inflammatory bowel ...
IL-11 induces Th17 cell responses in patients with early relapsing-remitting multiple sclerosis. J. Immunol. 194, 5139–5149 (2015). CAS PubMed Google Scholar Lucas, S., Ghilardi, N., Li, J. & de Sauvage, F. J. IL-27 regulates IL-12 responsiveness of naïve CD4+ T cells through...
The evidence supporting the view that multiple sclerosis is due to immunologic mechanisms comes from histological analysis of multiple sclerosis in humans, as well as work on experimental allergic encephalomyelitis (EAE) in animals. With respect to histological analysis, lesions found in the white matte...