The dynamics of chromatin organization regulates DNA accessibility to eukaryotic transcription and DNA repair complexes. However, the structural and dynamic properties of chromatin at high concentrations characteristic of the cellular environment (> ~200 mg/ml) are largely unexplored at......
In: Protein Folding and Misfolding: Neurodegenerative Diseases. Ovádi J, Orosz F, editor. New York, USA: Springer; 2008. Intrinsic disorder in proteins associated with neurodegenerative diseases; pp. 21–l75.Ovádi J, Orosz F (eds) (2009) Protein folding and misfolding: neurodegenerative ...
The proper folding of the protein (native fold) is responsible for the corresponding biological function. Many neurodegenerative diseases arise because of the misfolding of the protein, of which some are due to protein aggregation [8]. Sometimes the failure of the protein to fold into its native...
Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, s... (展开...
using energy fromATP. Chaperones can avoid the conformational change to beta sheet structure and the aggregation of these altered proteins; thus they seem fundamental to the prevention of protein misfolding. Despite chaperone actions, some proteins still misfold, but there is a remedy: The misfolded...
The second volume continues to fill the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of...
Structure-Based Prediction of Unstable Regions in Proteins: Applications to Protein Misfolding Diseases Protein misfolding is a necessary step in the pathogenesis of many diseases, including Creutzfeldt-Jakob disease (CJD) and familial amyotrophic lateral sclerosis (fALS). Identifying unstable structural el...
Mechanisms of protein misfolding: Novel therapeutic approaches to protein-misfolding diseases Protein misfolding occurs due to formation of non-native structure of protein.Environmental conditions and other factors influences the misfolding of prote... Parveen Salahuddin a,MKS A,SK B,... - 《Journal...
This is a preview of subscription content, log in via an institution to check access. Similar content being viewed by others Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond Article 21 May 2015 Protein misfolding in neurodegenerative diseases: implication...