Bacteriophage Therapies Targets Multiple Diseases Caused by Protein MisfoldingFilamentous bacteriophages (Ff) are a group of related viruses which infect only gram-negative bacteria They are flexible filaments of about 900 nm long and 610 nm thick, similar to amyloid fibrils The similarity in ...
Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, s... (展开...
In: Protein Folding and Misfolding: Neurodegenerative Diseases. Ovádi J, Orosz F, editor. New York, USA: Springer; 2008. Intrinsic disorder in proteins associated with neurodegenerative diseases; pp. 21–l75.Ovádi J, Orosz F (eds) (2009) Protein folding and misfolding: neurodegenerative ...
Protein strains Proteins that form the unique fibril structures that underlie the pathological presentation of a disease. Conformational strains Forms of a protein with distinct fibril structures. Prion diseases A family of neurodegenerative disorders caused by misfolded prion protein that affect both humans...
Therapeutic approaches to protein-misfolding diseases. Several sporadic and genetic diseases are caused by protein misfolding. These include cystic fibrosis and other devastating diseases of childhood as well a... FE Cohen,JW Kelly - 《Nature》 被引量: 1358发表: 2003年 Therapeutic approaches to ...
The general pattern that emerges in all these diseases is an abnormal tendency of proteins to aggregate as a result of misfolding. The aggregation can be caused by chance; by protein hyperphosphorylation (a condition where multiple phosphate groups are added to the protein), by prion self-catalyt...
The second volume continues to fill the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of...
The research concerned prion diseases – a group of brain diseases caused by proteins called prions that malfunction and ‘misfold’, turning into a form that can accumulate and kill brain cells. These diseases can take decades to manifest, but are then aggressive and fatal. ...
2002 Protein-misfolding diseases: getting out of shape. Nature 418, 729-730.C.M. Dobson, Protein-misfolding diseases: getting out of shape, Nature 418 (2002) 729-730.Dobson, C. M. Protein misfolding diseases: getting out of shape. Nature 2002, 418, 729-730....