Mitochondrial inheritance:In this unique type of inheritance, the mitochondria contain their own DNA. Only mitochondrial disorders caused by mutations in the mitochondrial DNA are exclusively inherited from mothers. If this is the way a mitochondrial disease ...
Mitochondrial dysfunction in neurodegenerative diseases. J Pharmacol Exp Ther 2012 ; 342:619 - 30; http://dx.doi.org/ 10.1124/jpet.112.192138 ; PMID: 22700435Johri A., Beal M. F. Mitochondrial dysfunction in neurodegenerative diseases. Journal of Pharmacology and Experimental Therapeutics . 2012;...
The accumulation of hydrophobic bile acids results in cholestatic liver injury by increasing oxidative stress, mitochondrial dysfunction, and activation of... Gumpricht,E. - 《Journal of Biological Chemistry》 被引量: 226发表: 2005年 Improved efficiency of hepatic mitochondrial function in rats with ...
Although fibrosis is a common pathological feature of most end-stage organ diseases, its pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction contributes to the development and progression of fibrosis. The heart, liver,
Mitochondrial dysfunction is the root cause of many diseases that are bewildering in their variety and complexity. They include rare genetic disorders in children, some forms of heart disease, and most likely many cases of Parkinson's disease. ...
Barot M, Gokulgandhi MR, Mitra AK. Mitochondrial dysfunction in retinal diseases. Curr Eye Res. 2011;36(12):1069-77.Barot M, Gokulgandhi MR, Mitra AK (2011) Mitochondrial dysfunction in retinal diseases. Curr Eye Res 36: 1069-1077....
- caused severe mitochondrial dysfunction in mice and impacted embryonic neurogenesis and the correct brain development. NSCs self-renewal, the proliferation of neural progenitor cells, their exit from the cell cycle, and the process of neuronal differentiation were all affected by AIF deletion [71]....
The latter is a process of growth and division of preexisting mitochondria rather than de novo synthesis, depending on the coordination of both mitochondrial and nuclear genomes [9]. Mitochondrial numbers are regulated by mitochondrial biogenesis to meet the energy demands of the cell, which process...
et al. High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio. Proc. Natl Acad. Sci. USA 107, 20087–20092 (2010). Article CAS PubMed PubMed Central Google Scholar Ross, J. M. et al. Germline mitochondrial DNA mutations aggravate ...
Early studies found that mitochondrial stress is caused by altered mitochondrial membrane potential or uncoupling of OXPHOS [41]. Later studies show that accumulation of unfolded proteins in the organelle also triggers UPRmt [42], [43], [44]. A number of Cross-talk between mitochondria and ER ...