American Journal of Medical Genetics Part C: Seminars in Medical GeneticsSuomalainen A, Kaukonen J (2001) Diseases caused by nuclear genes affecting mtDNA stability. Am J Med Genet 106:53–61Suomalainen, A. and Kaukonen, J. (2001) Diseases caused by nuclear genes affecting mtDNA stability. Am...
SFTS is an emerging tick-borne disease with high mortality rates caused by the SFTS virus. Here, the authors identify LRP1 as an entry factor for SFTSV, show that SFTSV glycoprotein Gn interacts with LRP1 and that blocking LRP1 reduces viral infection and improves survival in lethal mouse mod...
Glucosylceramide, which accumulates in Gaucher disease caused by homozygous mutations in GBA , compromises lysosomal function and leads to an accumulation of α -synuclein; conversely, α -synuclein inhibits GBA, resulting in an increase in glucosylceramide. CAS PubMed PubMed Central Google Scholar ...
Hadizadeh I, Peivastegan B, Hannukkala A, Van der Wolf J, Nissinen R, Pirhonen M (2019) Biological control of potato soft rot caused by Dickeya solani and the survival of bacterial antagonists under cold storage conditions. Plant Pathology 68:297–311 Article CAS Google Scholar Hamed HA...
Outbreaks from other spill-over transmissions in the last two decades include the swine acute diarrhoea syndrome originally caused by the transmission of an alpha-corona virus from bats to pigs in the People’s Republic of China and further: the Marburg virus from the African fruit bat to ...
Thus, compared to immunocompetent tissue, privileged tissues such as the eye are more prone to develop inflammatory diseases caused by GM alterations. A possible mechanisms is bacterial translocation from the gut to the eye. However, although many studies have shown that the GM contributes to the...
To answer this question, scientists based at the New York Genome Center (NYGC) and Columbia University have delved into large genomic datasets to find an explanation for variable penetrance, that is, variability in the signs and symptoms of diseases caused va...
The scary part of is not just the presence of the pathogen; it's the disease that's caused by that pathogen and/or our body's reaction to it. This lesson will go over some of the many diseases bloodborne pathogens may cause, and what they can do to our bodies. Lesson...
Chronic diseases are caused by complex gene-environment interactions acting across the lifespan from the fetus to old age (Figure 1). In this context, 'environment' includes risk and protective factors associated with environment and lifestyle, such as tobacco, nutrition, indoor and outdoor air ...
This study reports patients with MIRAGE syndrome, caused by germline heterozygous gof mutations in SAMD9, in whom somatic monosomy 7, interstitial 7q deletion or lof mutation in SAMD9 in blood cells represents recurrent SGR that eliminates the deleterious effect of the germline mutation and leads...