American Journal of Medical Genetics Part C: Seminars in Medical GeneticsSuomalainen A, Kaukonen J (2001) Diseases caused by nuclear genes affecting mtDNA stability. Am J Med Genet 106:53–61Suomalainen, A. and Kaukonen, J. (2001) Diseases caused by nuclear genes affecting mtDNA stability. Am...
Neurodegenerative disorders caused by genetic and environmental factors result in loss of integration and function of neurons and even neuronal death. Since the world population is aging rapidly, numerous studies have been conducted to understand the molecular mechanisms in the pathogenesis of neurodegenerat...
aThe findings present a chicken-versus-egg problem, Blekhman says. Still undetermined is if the bacteria are triggering disease in people who carry certain genetic variants, or if the diseases caused by genetic variants lead to more growth of some types of bacteria. [translate] ...
Immune disorders caused by a genetic defect are usually evident early in life.免疫系统的机能丧失可能有很多原因。由遗传缺陷造成的免疫疾病通常在生命早期就可看出。 16.The Analysis of Genetics and Associated Autoimmune Diseases in Chinese Vitiligo Patients;白癜风的遗传与相关自身免疫性疾病研究 17.Autoimmune...
Albers-Schonberg disease, marble bones disease, osteopetrosis - an inherited disorder characterized by an increase in bone density; in severe forms the bone marrow cavity may be obliterated nevoid elephantiasis, pachyderma - thickening of the skin (usually unilateral on an extremity) caused by conge...
According to estimates, diseases caused by mtDNA mutations affect at least one in every 5,000 people worldwide. However, the frequency of pathogenic mtDNA mutations is about one in 200. The mutation m.3243A>G, which causes MELAS syndrome (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke...
Most disorders are caused by a combination of multiple genetic and/or environmental factors. If two diseases are caused by the same molecular mechanism, they tend to co-occur in patients. Here we provide a quantitative method to disentangle how much gene
Discrimination against people with chronic disabilities (primarily caused by genetics) might take the form of job rejection, health insurance denial, or just social acceptability. This leads to the marginalization of these individuals and significantly compromises the principles and goals of public health...
To answer this question, scientists based at the New York Genome Center (NYGC) and Columbia University have delved into large genomic datasets to find an explanation for variable penetrance, that is, variability in the signs and symptoms of diseases caused ...
Immune imbalance caused by dysbiosis under the combined effect of gene environment in IgE-related FA. During childhood, the human microbiota is influenced by a combination of the maternal microbiome, mode of delivery, genetics, epigenetics, environment, etc. Dysbiosis resulting from aberrant damage to...