Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review. European journal of medicinal chemistry 2016;124:1121-1141.H. Khanam, A. Ali, M. Asif, Shamsuzzaman, Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: a review, ...
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Under normal circumstances, the cell has mechanisms to prevent proteins from folding incorrectly, as well as to get rid of misfolded proteins. Proteins that have problems achieving their native configuration are helped by chaperones to fold properly, using energy fromATP. Chaperones can avoid the con...
dementia causing diseases and associated ailments in the future. Today approximately more than 35 proteins have been identified capable of forming amyloids under defined conditions, and nearly all of them have been associated with disease outcomes. This review incorporates a major understanding from the ...
but also in patients with Alzheimer`s disease, sPrP relocalizes from a physiological diffuse tissue pattern to intimately associate with extracellular aggregated deposits of misfolded proteins characteristic for the respective pathological condition. Findings and research tools presented here will accelerate ...
Furthermore, both of these proteins have been found associated with exosomes, suggesting a potential role of EVs in the intercellular transfer of misfolded SOD1 and TDP43 (94, 95). It has also been demonstrated that huntingtin, the pathogenic protein that misfolds in Huntington's disease, can...
In vitro experiments, researchers have found that mutated mSOD1 protein can also activate microglia, possibly through CD14 (a pattern recognition receptor for misfolded proteins), as CD14 shares common receptors TLR-2 and TLR-4. Similar to LPS, mSOD1 can bind to CD14. After using antibodies ...
Amyloid fibers and oligomers are associated with a great variety of human diseases including Alzheimer's disease and the prion conditions. Here we attempt to connect recent discoveries on the molecular properties of proteins in the amyloid state with observations about pathological tissues and disease ...
Atom RSS Feed Prion diseases are a group of progressive neurodegenerative diseases that are caused by misfolded proteins, referred to as prions. During post-translational modification of proteins, prions act as a folding template, converting proteins into infectious prion form. The best-known human pr...
We will also describe the molecular basis and implications for prion-like conformational strains, cross-interaction between different misfolded proteins in the brain, and how these concepts can be applied to the development of novel strategies for therapy and diagnosis. This is a preview of ...