Extremely close association of HLA-B27 and ankylosing spondilitis has been observed in Japanese as well as the other races, but as to the other B27 related diseases the association is not clear in Japanese. HLA antigens associated with type I diabetes mellitus in Japanese are HLA-Bw54, DR...
Human leukocyte antigen (HLA) class I association is a well-established feature of common and uncommon inflammatory diseases, but it is unknown whether it impacts the pathogenesis of these disorders. The “arthritogenic peptide” hypothesis proposed initially for HLA-B27-associated ankylosing spondylitis...
In fact, individuals expressing specific HLA alleles are more susceptible to suffer from specific auto-inflammatory and autoimmune diseases. For instance, birdshot chorioretinopathy was shown to be associated with HLA-A29, ankylosing spondylitis with HLA-B27, Behçet’s disease with HLA-B51 and ...
The mechanisms underlying the genetic association between HLA-B27 and ankylosing spondylitis, including the contribution of endoplasmic reticulum aminopeptidase 1 (ERAP1), continue to elude the field. New findings support the involvement of the unfolded protein response and highlight the therapeutic potenti...
B选项正确:强直性脊柱炎与MHC I类等位基因HLA-B27相关,说明MHC I类等位基因在自身免疫病中存在关联。C选项正确:分子拟态是自身免疫病的机制之一,例如链球菌M蛋白与心肌细胞的交叉反应导致风湿热。因此,A、B、C均正确,正确答案为E。反馈 收藏
The aim of the present study was to study the association of HLA B27, B7, Bw4 and Bw6 with some inflammatory diseases, in SSA patients in our area. A total of 220 SSA patients were studied and HLA typing for these antigens were done by the complement-mediated microcytotoxicity method. ...
Joint:peripheral arthritis—parallels activity of bowel disease; ankylosing spondylitis and sacroiliitis (associated with HLA-B27)—activity independent of bowel disease Skin:erythema nodosum, aphthous ulcers, pyoderma gangrenosum, cutaneous CD Eye:conjunctivitis, episcleritis, iritis...
Meyer O, Vignoli M, Ryckewaert A: Unclassifiable inflammatory rheumatism with HLA B27. Rev Rhum Mal Osteoartic 49:11–16, 1982 PubMedCASGoogle Scholar Rose E, Espinoza LR, Osterland CK: Intestinal bypass arthritis: Association with circulating immune complexes and HLA B27. J Rheumatol 4:129–...
HLA-B27 Rheumatoid factor (RF) They'll finish up with imaging tests such as X-rays, an MRI or a CT scan to check for joint damage. Read more for anoverview on juvenile rheumatoid arthritis. Reactive Arthritis What is it?Reactive arthritis is caused by an infection in another part of you...
and bone erosions. Clinical manifestations include reduced mobility of joints and the spine with severe chronic pain. AS has a genetic association with HLA-B27. It is commonly known that its main pathogenesis comprises systemic inflammation and osteogenesis, but the interaction between its genotype an...