Other cholinergic drugs such as muscarinic agonists have been explored, and although they are not approved, there is robust preclinical evidence for a beneficial, perhaps disease-modifying effect. This review summarizes evidence suggesting that these drugs may do more than improve symptoms; they may ...
MMP-13 and ADAMTS-5, two critical catabolic enzymes responsible for the degradation of type II collagen and aggrecan, respectively, have been the prime targets of RNA-based therapies. Hoshi et al. examined the effect of chemically modifiedMmp13orAdamts5siRNA, alone or in combination, in a post...
activity. Valproic acid inhibited GSK-3β, which resulted in a cytoprotective effect. While this disease mechanism still awaits confirmation in patients with BD, the striking results suggest abnormal GSK-3β activity as a common link between BD and diabetes mellitus supported by a potentially similar...
Gantenerumab's ability to bind both to the flexible N-terminal portions of Aβ and to adja- cent central portions of fibrillar Aβ is thought to confer greater binding stability, considered important for ther- apeutic effect [10]. Gantenerumab mechanism of action: target engagement of A...
Gantenerumab’s ability to bind both to the flexible N-terminal portions of Aβ and to adjacent central portions of fibrillar Aβ is thought to confer greater binding stability, considered important for therapeutic effect [10]. Gantenerumab mechanism of action: target engagement of Aβ, especially...
CNTF-derived neurogenic/neurotrophic compound, P021, can exert a disease-modifying effect in a transgenic mouse model of AD A widely prevalent hypothesis regarding the role of neural stem cells–based therapy for neurological disorders is that of the “bystander” effect mechanism of neural stem cel...
O. et al. The effect of dimethyl fumarate (Tecfidera) on lymphocyte counts: a potential contributor to progressive multifocal leukoencephalopathy risk. Mult. Scler. Relat. Disord. 4, 377–379 (2015). Article PubMed Google Scholar Spencer, C. M., Crabtree-Hartman, E. C., Lehmann-Horn, K...
(group effect and interaction effect; group × time point), body weights were significantly different (p< 0.01) in the groups mentioned above during the 29-day course of the experiment. Therefore, differences in body weight at each time point were analyzed between the PBS_vehicle and BLM_...
Our study is one of the largest pediatric prospective longitudinal analyses of the effect of DMTs on the TRV trajectory in SCA. Here, we showed that hydroxyurea use was associated with a small, but significant, decrease in mean TRV over a 2-year period. At baseline, the prevalence of ...
66 However, the biological effect of TGF-β is under complex control, and may switch from being protective in normal joints to detrimental in OA as a result of changes in the predominant cell-surface receptors and intra-cellular signalling pathways in various joint tissues (cartilage...