To test whether multidisease states could be equally informative from readily accessible information from study participants at baseline, we investigated three different scenarios with increasingly comprehensive predictor sets. First, we considered age and sex only, both highly predictive for common diseases...
5d). This interestingly is the reverse of overall gut bacterial richness, which decreases with urbanization41. Abundance, measured as the fraction of reads that mapped to Ca. Heliusvirales TerL genes, was not significantly different between the three populations (Supplementary Fig. 10b). Ca. ...
The offspring, with a different genetic background, may very well be a cat with fast progressing disease. Thus, like PKD, the HCM disease-causing variant should be balanced with other good attributes of breeding cats and considered for slow eradication from a breed. A common suggestion is to...
That is, different diseases with same "tissue-of-origin" tend to have similar pathogenesis. Taken together, the traditional disease taxonomy which classifies diseases based on "tissue-of-origin" is reasonable from the viewpoint of disease network in terms of dys- functional regulatory mechanisms. ...
A different hypothesis emphasizes that positive effects can be achieved, even in the face of severe mutations, if treatment is to begin very early, perhaps in a baby intentionally delivered prematurely. This latter hypothesis is consonant with the notion that some of the pathology begins in utero...
Different mixtures have different effects on the waves, and, with a bit of training, a computer loaded with an appropriate piece of artificial intelligence can learn to recognize the pattern associated with sebum from Parkinson’s patients.The researchers tested their system on samples from 43 ...
with the single exception of the dopaminergic SNpc, where higher levels of CI deficiency are observed, albeit to a lesser extent than in CI-PD. Importantly, this difference is not driven by disease duration or age, indicating that it does not reflect two different stages of the same process...
We next performed TF deviation analysis on monocyte subsets, we noticed monocyte subsets exhibited deviated variations in different TF family members from homeostasis to the activated effector state (Supplementary Fig.11d). For example, both ActCM and ActNCM were associated with high levels of activity...
The amount of total mitochondrial numbers and morphology was determined using two different independent stainings. On one hand, we stained the ATP synthase with an antibody against ATP5F1A in hNPCs (Fig. 2a) and DAns derived thereof (Fig. 2b). To specifically visualize functional/active mitocho...
Heatmap colors (>10% of cells associated) and cross symbols are omitted for cell-type–disease pairs with nonsignificant cell-type–disease associations via MC test. We matched each TMS FACS cell type using the closest cell type in the TMS droplet and TS FACS data; unmatched cell types were...