This article provides compelling evidence that Aβ accumulation preferentially starts in the DMN. Article PubMed PubMed Central CAS Google Scholar Buckner, R. L. & DiNicola, L. M. The brain’s default network: updated anatomy, physiology and evolving insights. Nat. Rev. Neurosci. 20, 593...
It is a chronic disease that usually starts slowly with a pre-symptomatic phase and worsens over time2. Early diagnosis is essential for successful disease management and chance to attenuate symptoms by disease modifying drugs. In the past, a number of cerebrospinal fluid (CSF), plasma and ...
“dopamine”—a chemical that works as a neurotransmitter for controlling movements in different parts of the body. The degenerative process starts from the base of the brain, leading to the destruction of olfactory bulbs, followed by the lower brain stem and subsequently substantia nigra and mid...
that patients treated relatively recently had lower ESR values and that those cases with recent onset RA, stratified by quartiles of ESR, maintained their position over time. There is often talk of ‘burnt-out’ rheumatoid, implying that RA patients reach a stage in their disease duration when...
novo-ulmi populations for the choice of pathogen inoculum when screening; (4) the possibility of using active resistance to the pathogen in the beetle feeding wound, and low attractiveness of elm cultivars to feeding beetles, in addition to resistance in the xylem; (5) the risk that genes ...
forming a ‘metastable subproteome’ that is highly susceptible to misfolding (Tartaglia et al.2007). These features likely overlap with the functional use of liquid–liquid phase-separation of biomolecules (proteins and nucleic acids) in cells, a process that needs to be closely regulated to avo...
The science of networks has revolutionised research into the dynamics of interacting elements. It could be argued that epidemiology in particular has embraced the potential of network theory more tha...
extracellular soluble APP (sAPP), which may function in cellular signalling, an intracellular domain with possible cell-autonomous functions, and small membrane fragments. The β-secretase and γ-secretase path produces Aβ, a small peptide that was shown to be the primary constituent of amyloid ...
Dynamic regulation of alternative splicing by silencers that modulate 5′ splice site competition. Cell 135, 1224–1236 (2008). Article CAS PubMed PubMed Central Google Scholar Plaschka, C., Lin, P. C., Charenton, C. & Nagai, K. Prespliceosome structure provides insights into spliceosome ...
Functional screening identified that VCAM1 directs microglial Aβ chemotaxis by sensing Aβ plaque-associated ApoE. Moreover, we found that disrupting VCAM1–ApoE interaction abolishes microglial Aβ chemotaxis, resulting in decreased microglial clearance of Aβ. In patients with AD, higher ...