“dopamine”—a chemical that works as a neurotransmitter for controlling movements in different parts of the body. The degenerative process starts from the base of the brain, leading to the destruction of olfactory bulbs, followed by the lower brain stem and subsequently substantia nigra and mid...
This article provides compelling evidence that Aβ accumulation preferentially starts in the DMN. Article PubMed PubMed Central CAS Google Scholar Buckner, R. L. & DiNicola, L. M. The brain’s default network: updated anatomy, physiology and evolving insights. Nat. Rev. Neurosci. 20, 593...
As references, we show with a method based on a vanilla supervised neural network (orange) and also the hidden layer of the shallow autoencoder 512 nodes (shallowAE; magenta). MS. c The Fisher’s combined p value across all eight diseases predicted by a three-layer deep autoencoder. The...
Changes with time In most patients, RA remains active over the years, with a gradual variation from month to month and year to year in the absolute level of activity. Initially, DAS falls as treatment starts to take effect. Thereafter it remains elevated, but not on average very high. An...
Age at onset can vary from 6 to 94 years old with a mean of 40 ± 9.9 to 58.9 ± 12.6 according to studies. Progression of the disease can also vary from 8 months to 18.7 ± 11.4 years. Most of the time, familialSOD1ALS starts with an asymmetric weakness in a ...
Electrophysiological properties of adult cardiomyocytes can be described by their AP profile, which is widely considered specific for each cardiomyocyte subtype (atrial, ventricular, pacemaker, and Purkinje). However, independent of subtype, AP always starts with a rapid influx of Na+as a rapid depola...
Each chapter starts with Key Points that crystallize current knowledge. The chapters on the Burden of COPD and Risk Factors demonstrate the global importance of COPD and the various causal factors involved. The chapter on Pathology, Pathogenesis, and Pathophysiology documents the current understanding ...
Shared medical appointments are a series of one-to-one doctor-patient contacts, in presence of a group of 6-10 fellow patients. This group visits substitute the annual control visits of patients with the neurologist. The same items attended to in a one-to- one appointment are addressed. The...
R., Sarma, A., Sharp, P. A. & Burge, C. B. Proliferating cells express mRNAs with shortened 3′ untranslated regions and fewer microRNA target sites. Science 320, 1643–1647 (2008). Article CAS PubMed PubMed Central Google Scholar Oh, J. M. et al. U1 snRNP regulates cancer cell...
Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progression is not fully understood. Here, we showed that neural precursor...