This article provides compelling evidence that Aβ accumulation preferentially starts in the DMN. Article PubMed PubMed Central CAS Google Scholar Buckner, R. L. & DiNicola, L. M. The brain’s default network:
“dopamine”—a chemical that works as a neurotransmitter for controlling movements in different parts of the body. The degenerative process starts from the base of the brain, leading to the destruction of olfactory bulbs, followed by the lower brain stem and subsequently substantia nigra and mid...
R., Sarma, A., Sharp, P. A. & Burge, C. B. Proliferating cells express mRNAs with shortened 3′ untranslated regions and fewer microRNA target sites. Science 320, 1643–1647 (2008). Article CAS PubMed PubMed Central Google Scholar Oh, J. M. et al. U1 snRNP regulates cancer cell...
Changes with time In most patients, RA remains active over the years, with a gradual variation from month to month and year to year in the absolute level of activity. Initially, DAS falls as treatment starts to take effect. Thereafter it remains elevated, but not on average very high. An...
Electrophysiological properties of adult cardiomyocytes can be described by their AP profile, which is widely considered specific for each cardiomyocyte subtype (atrial, ventricular, pacemaker, and Purkinje). However, independent of subtype, AP always starts with a rapid influx of Na+as a rapid depola...
Shared medical appointments are a series of one-to-one doctor-patient contacts, in presence of a group of 6-10 fellow patients. This group visits substitute the annual control visits of patients with the neurologist. The same items attended to in a one-to- one appointment are addressed. The...
Dutch elm disease (DED) is a vascular wilt disease caused by the pathogens Ophiostoma ulmi and Ophiostoma novo-ulmi with multiple ecological phases including pathogenic (xylem), saprotrophic (bark) and vector (beetle flight and beetle feeding wound) phases. Due to the two DED pandemics duri...
[6], in a variety of cell types, including capillary endothelial cells, renal (podocytes, tubular cells, glomerular endothelial, mesangial and intersticial cells), cardiac (cardiomyocytes and fibroblasts) and nerve cells [7]. The primary disease process starts in infancy, or even as early as ...
a–c, IL-33 induces prolonged expression of the microglial chemotactic gene signature. a, Heatmap showing the expression levels of 1,433 IL-33-induced genes in microglia 3, 8 and 24 h after IL-33 treatment (adjusted P value < 0.05). The bar on the far right indicates genes show...
IVT mRNA is an ssRNA containing a 5′ cap structure, an ORF, flanking 5′ and 3′ UTRs and a 3′ poly (A) tail [73]. The optimization of mRNA vaccines often starts from these five structures through sequence optimization, nucleoside modification or sequence substitution of UTRs to enhance...