“dopamine”—a chemical that works as aneurotransmitterfor controlling movements in different parts of the body. The degenerative process starts from the base of the brain, leading to the destruction ofolfactory bulbs, followed by the lowerbrain stemand subsequently substantia nigra and midbrain[18...
This article provides compelling evidence that Aβ accumulation preferentially starts in the DMN. Article PubMed PubMed Central CAS Google Scholar Buckner, R. L. & DiNicola, L. M. The brain’s default network: updated anatomy, physiology and evolving insights. Nat. Rev. Neurosci. 20, 593...
Disease course mapping is a statistical technique which allows the decomposition of these two types of variations seen in a longitudinal data set. It builds on abstract geometric principles so that it is not specific to particular data11,12. It combines the concept of time-warp with translations...
CSF biomarkers for the early diagnosis of Alzheimer's disease in a routine clinical setting - The first Portuguese study Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disorder, and it is known that the underlying pathology starts years before clinical symptoms. Therefore...
Each chapter starts with Key Points that crystallize current knowledge. The chapters on the Burden of COPD and Risk Factors demonstrate the global importance of COPD and the various causal factors involved. The chapter on Pathology, Pathogenesis, and Pathophysiology documents the current understanding ...
P-tau levels in paired plasma and serum correlated strongly with each other (rho=0.75–0.93) as well as with CSF Aβ42 (rho= −0.56 to −0.59), p-tau and total-tau (rho=0.53–0.73). Based on the results, it seems possible that serum p-tau reflects the same pool of brain-...
Introduction: Hypertension is common in chronic kidney disease and plays a pivotal role in progression of renal dysfunction. The pathogenesis of hypertension in CKD is multifactorial. The stage at which the sympathetic activity starts to rise is still unclear. Hence this study was conducted to study...
The model also needs to be initialised with the initial condition u0 and tspan, a vector of time points where the state of the system is to be returned. Let us create a model that consists of 1000 replicates of a population, denoted a node in SimInf, that each starts with 99 ...
As references, we show with a method based on a vanilla supervised neural network (orange) and also the hidden layer of the shallow autoencoder 512 nodes (shallowAE; magenta). MS. c The Fisher’s combined p value across all eight diseases predicted by a three-layer deep autoencoder. The...
relevant to treatment. For each drug and disease pair, we induce a subgraph on thekmost frequently visited nodes in the drug and disease diffusion profiles to explain treatment.fDrugs with more similar diffusion profiles have more similar gene expression signatures (Spearmanρ = 0.392,p =...