Multiple sclerosis (MS) is an inflammatory disease of the CNS that is characterized by a demyelination of axons in inflammatory plaques which leads to a deficiency or complete loss in the transmission of nerve impulses. The majority of patients have either relapsing remitting multiple sclerosis (RRMS...
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white matter are similar to that of control white matter (not shown). In addition to whether the pathological changes by Henderson and colleagues can be translated to the more standard MS pathology setting, future studies should also take early degenerative changes within the axons into account. ...
Stimulated by the successful introduction of interferon-β as treatment for relapsing-remitting multiple sclerosis (MS) and based on an improved knowledge of the immunopathology of MS, a vast array of treatment options is currently under investigation for disease course modification. These are targeting...
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Lesions of the cerebellum and brainstem may appear similar to demyelinating diseases such as multiple sclerosis [38]. ECD related suprasellar lesions should be considered in the differential diagnosis alongside Langerhans cell histiocytosis or other adenomatous, granulomatous or inflammatory processes of this...
Selective loss of myelin and OLs contributes to the pathogenesis of progressive neurodegenerative diseases such as multiple sclerosis (MS) (Trapp and Nave, 2008) and leukodystrophies (Knaap and Bugiani, 2017). Similarly, white matter degeneration and myelin loss have been observed in other ...
Multiple sclerosis (MS) is the most common chronic inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults. This disorder is a heterogeneous, multifactorial, immune-mediated disease that is influenced by bo
The assessment of disease activity in systemic sclerosis (SSc) is challenging owing to its heterogeneous manifestations across multiple organ systems, the variable rate of disease progression and regression, and the relative paucity of patients in early-phase therapeutic trials. Despite some recent succes...
People with multiple sclerosis (MS) face challenges adhering to disease-modifying drug (DMD) treatment. Poor adherence to treatment reduces its clinical ef