Relapses were defined as neurologic symptoms lasting more than 24 hours; not associated with infection, fever, or heat intolerance; and deemed to require corticosteroids and were documented by an investigator who was not masked to treatment assignment. T2-weighted lesion volume on MRI was reported ...
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable; existing treatments for AD produce only a modest amelioration of symptoms. Research into this disease has conventionally focused on the CNS. However, several peripheral and systemic abnormalities are now understood...
With an increasing number of treatment-associated infections, accurate diagnostic work-up of patients with MS who present with new neurological symptoms becomes crucial Owing to the possibly serious or even fatal complications of modern MS treatment options, safety data on infections must be collected ...
While crop damage due to SCN is devastating, the symptoms above the ground level are not every time noticeable, and infestations are typically only identified in the advanced phase of infection. At this stage, a significant amount of damage has already taken place. Symptoms include chlorosis, stu...
Individuals with SCD report health-related quality of life similar to that of individuals undergoing hemodialysis.51 Furthermore, this study only considered the association between pain and overall health-related quality of life, ignoring other symptoms, and therefore is likely an underestimation of the...
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On subjects belonging to families that were previously followed in our department, age of onset was considered when patients became symptomatic (SARA score superior to 4); non-ataxic symptoms were questioned and evaluated particularly considering oculomotor abnormalities and peripheral nerve involvement. ...
we conducted an additional greenhouse experiment where we comparedR. solanacearumcell and phage particle densities over time. We found that inoculation of a four-phage combination [22] clearly reduced both disease symptoms (53.13%, Fig.3e) and pathogen densities (25.83%, Fig.3f) relative to the...
combinations of patient-specific mechanisms co-vary with specific clinical symptoms. Sector colors represent the output pathological factor of each model, named in the inner (central) sectors. For each mechanism, the angle is proportional to the percentage of mechanistic-clinical covariance explained. ...
Parkinson’s disease (PD) can be classified into an akinetic-rigid (AR) and a tremor-dominant (TD) subtype based on predominant motor symptoms. Patients with different motor subtypes often show divergent clinical manifestations; however, the underlying n