Structure-Function Analysis of the Coiled-Coil and Leucine-Rich Repeat Domains of the RPS5 Disease Resistance Protein.The Arabidopsis (Arabidopsis thaliana) RESISTANCE TO PSEUDOMONAS SYRINGAE5 (RPS5) disease resistance protein mediates recognition of the Pseudomonas syringae effector protein AvrPphB. R...
We describe a method to engineer disease resistance in plants by means of an endogenous disease resistance gene from Arabidopsis thaliana named RPS5, which encodes a nucleotide-binding leucine-rich repeat (NLR) protein. RPS5 is normally activated when a second host protein, PBS1, is cleaved by...
A. Molecular mechanisms regulating glucocorticoid sensitivity and resistance. Mol. Cell. Endocrinol. 300, 7–16 (2009). CAS PubMed Google Scholar Oakley, R. H. & Cidlowski, J. A. Cellular processing of the glucocorticoid receptor gene and protein: New mechanisms for generating tissue-specific...
R protein-mediated disease resistance results in strong host responses, often culminating in a hypersensitive response (HR) and the production of reactive oxygen species (ROS) (Heath, 2000). The biphasic production of apoplastic ROS, the so-called “oxidative burst,” is a hallmark of successful...
et al. Characterization of in vivo resistance to osimertinib and JNJ-61186372, an EGFR/Met bi-specific antibody, reveals unique and consensus mechanisms of resistance. Mol. Cancer Ther. https://doi.org/10.1158/1535-7163.MCT-17-0413 (2017). Huang, P. H. et al. Phosphotyrosine signaling ...
protein disulphide isomerases; p50-ATF6, transcriptionally active transcription factor 6; p97, the ATP-driven chaperone valosin-containing proteinvalosin-containing protein; p180, ribosome receptor; PERK, protein kinase R-like ER kinase; Png1, an N-glycanase; RBX1, E3 ubiquitin-protein ligase RBX1...
Notably, it has been established that NDR1-driven resistance is dependent on a specific subset of R-proteins (such as RPM1, RPS2 and RPS5) that are defined by the presence of a coiled-coil (CC) structure within their N-terminal parts [23]. From a mechanistic perspective, the best ...
Insulin‐Like Growth Factor I Resistance Intellectual Disability Syndrome Intellectual Disability with Language Impairment and Autistic Features Intellectual Disability, Dominant Intellectual Disability, Recessive Intellectual Disability, Stereoty...
on the disease outcome61. In human breast cancer biopsies, cancer cells sometimes accumulate the metastatic lymph node gene 51 (MLN51) RBP, in discrete cytoplasmic foci resembling SGs45, which is in line with studies that have associated SG formation to the resistance to chemotherapeutic drugs62....
et al. A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric NO-dependent and gut-brain axis mechanism. Cell Metab.26, 278 (2017). CAS PubMed Google Scholar Fu, J. et al. The gut microbiome contributes to a substantial proportion of the...