These loci are linked with three widely known disease‐related genes, namely, resistance gene analogue 3 ( RGA3 ), resistance gene analogue 4 ( RGA4 ) and receptor‐like protein 9a ( RLP9a ). The loci identified here can be used for marker‐assisted selection when developing leaf spot ...
protein 4; PBS1, the disease resistance protein PBS1) showed up-reregulated gene expression pattern at the early stage of Xoo infection (Fig. 2). In addition, the downstream HSP90 (heat shock protein 90) was found down-regulated at the early stage (TE/CO) followed by up-regulated at...
hypoxia-related genes [206]. ST on FFPE human prostate cancer revealed that luminal cells in tumors are greatly expanded in the invasive carcinoma region and did not co-localize with basal cells [207,208]. ST also provides new insights into drug resistance tumor cells. ST analysis of paired ...
PERK activation results in the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), which reduces the general protein translation to relieve the ER workload. eIF2α selectively enhances the production of the stress-inducible transcription factor, ATF4. It activates to express the ...
A PR protein-induced hypersensitive response (HR) may play a role in mediating defense in EBDC-resistant tomato breeding lines, with the hypothesis that a functional difference between toxin-induced cell death and the programmed cell death (PCD) of HR underlies the resistance [22]. Furthermore,...
Hepatitis C virus infection: molecular pathways to steatosis, insulin resistance and oxidative stress. Viruses 1, 126–143 (2009). 42. Fox, J. G. et al. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nat ...
lncRNAs regulate disease resistance-related genes intrans To shed light on the potential regulation of lncRNAs on protein-coding genes, we investigated bothtransandcistargets of DElncRNAs. lncRNAs can modulate the expression of distant genes throughtransmechanisms, involving chromatin remodeling or post-tr...
Most of HERVs are nonprotein-coding because of the accumulation of mutations, insertions, deletions, and/or truncations. It has been long thought that HERVs were “junk DNA”. However, it is now known that HERVs are involved in various biological processes through encoding proteins, acting ...
Arancibia-Carcamo CV, Coles M, Gaffney E, Travis SP, Denson L, Kugathasan S, Schmitz J, Powrie F, Sansom SN, Uhlig HH (2021) Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance....
Progression of the metabolic dysfunction-associated steatotic liver disease. MASLD encompasses a broad clinical spectrum of liver damage. First, when exposed to some risk factors (e.g. insulin resistance, type 2 diabetes mellitus, obesity, hypertension, dyslipidemia) simple macrovesicular steatosis (MAS...