GPR37-enhanced ubiquitination of ATP1A1 inhibits tumor progression and radiation resistance in esophageal squamous cell carcinoma Jiaru Hu Fang Meng Liting Qian ArticleOpen Access27 Dec 2024 TRIM59/RBPJ positive feedback circuit confers gemcitabine resistance in pancreatic cancer by activating the No...
Autophagy: a critical mechanism of N6-methyladenosine modification involved in tumor progression and therapy resistance Feiyang Wang Qiudi Liao Ming Zhou Review ArticleOpen Access28 Oct 2024 Metabolic gatekeepers: harnessing tumor-derived metabolites to optimize T cell-based immunotherapy efficacy in the tu...
In a large adult cohort with CKD, hematuria was associated with a significantly higher risk of CKD progression and death in the first 2 years of follow-up but did not improve risk prediction. The online version of this article (10.1186/s12882-018-0951-0) contains supplementary material, ...
Main results Patients who died within 14, 90, or 180days were more likely to have disease progression than those who did not. Dyspnea on emergency center presentation and disease progression were independent predictors of death within 90 or 180days, after controlling for patient age, symptoms, ...
(A–D) Progression to new AIDS/death: role of late presentation or late presentation with advanced disease: COHERE 2000–2011.Amanda MocroftJens D. LundgrenMiriam Lewis SabinAntonella d'Arminio MonforteNorbert BrockmeyerJordi CasabonaAntonella Castagna...
Several therapeutic approaches have been developed to reduce the symptom burden and the probability of progression into severe or critical illness. These mainly include antivirals (e.g. nirmatrelvir-ritonavir, monulpiravir, VV116) [4,5,6], monoclonal antibodies (e.g. tixagavimab-cilgavimab, ...
TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathway Yao Xi ,Rui Xu &Yohei Niikura Perspective 15 November 2024|Open Access NINJ1: Bridging lytic cell death and inflammation therapy ...
Recent studies have revealed that FAPs from dystrophic muscles of mdx mice – the DMD mouse model – retain a phenotypic and functional bipotency, as they can either support compensatory regeneration at early stages of disease progression, or mediate fibrotic and fat deposition (Figure 4).12,16Th...
Another EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin) trial is investigating the effects of empagliflozin (10 mg/day) on kidney disease progression or cardiovascular death compared with placebo. The results have not yet been announced [85]. 5.1.3. Dapagliflozin ...
Previous studies have reported that males with chronic hepatitis B and C had greater progression rate to fibrosis compared with females[23, 24]. Although women tended to develop ALD after exposure to the same amount of alcohol than men, the higher proportion of high alcohol consumption was ...