p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment Darya Yanushko Beatriz German Falcon Daniel Metzger ArticleOpen Access26 Jan 2025 MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the ...
In the field of metabolic diseases, we are proud of our portfolio of stable and effective animal models, especially those for Non-alcoholic Fatty Liver Disease (NAFLD). Though popular recently, they still lack effective drug treatment.
Targeting estrogen-regulated system xc−promotes ferroptosis and endocrine sensitivity of ER+ breast cancer Jiawei Cao ,Tong Zhou &Haihua Gu Article 19 January 2025|Open Access ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability ofNntmRNA through the Zic3-ApoM...
Because autoimmune diseases and their respective animal models are highly diverse, the focus here will be on one condition that includes the relevant considerations for using autoimmune animal models: this condition is arthritis. View chapterExplore book ...
Formaly disease or condition obesity is associated with a variety of diseases such as type 2 diabetes, atherosclerosis, cardiovascular diseases and certain cancers, and may also be responsible for high rates of morbidity and mortality. Understanding the pathophysiology of obesity has grown significantly...
Loss of immunoglobulins into the urine may increase the risk of infection, with susceptibility to bacteria or viral infections such asvaricella. Finally,systemic disorderssuch as diabetes oramyloidosismay simultaneously injure the kidneys and nervous system, from brain toperipheral nerves....
Variants inSART3cause a spliceosomopathy characterised by failure of testis development and neuronal defects TheSART3gene encodes an RNA-binding protein critical for spliceosome function. Here, the authors find that bi-allelic variants inSART3underlie a congenital condition characterised by neuro-developme...
symptoms are as described above for hypothyroidism. If this occurs in the fetus, infant, or young child, it results in the serious condition known as congenital hypothyroidism orcretinism. This condition affectsCNS developmentand maturation and results in permanent mental retardation, neurological defect...
Autoimmune hemolytic anemia, a condition in which the immune system attacks the red blood cells, is also more common in Crohn's disease and may cause fatigue, a pale appearance, and other symptoms common in anemia. 参考译文:自身免疫溶血性贫血是一种免疫系统攻击红细胞的疾病,也更常见于克罗恩病...
Disorders of almost any body system can adversely impact upon the mouth. Oral manifestations may be: 1) the first, only or most severe feature of systemic disease; 2) the principle focus of therapy; and/or 3) the dominant cause of a lessening of the affected person's quality of life. ...