Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder, which is characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular amyloid β plaques are one of the pathological hallmarks of AD. The autophagic lysos
The prevalence of urolithiasis in humans is increasing worldwide; however, non-surgical treatment and prevention options remain limited despite decades of investigation. Most existing laboratory animal models for urolithiasis rely on highly artificial me
PLS1 (plastin 1, I-plastin) is expressed in the intestine, colon, kidney and hair cell stereocilia of the inner ear, PLS2 (plastin 2, L-plastin) in hematopoietic cell lineages and many types of cancer cells, and PLS3 (plastin 3, T-plastin), the most abundant isoform, in cells...
The thyroid was normal. Breasts were Tanner 5; public hair was Tanner 3. The external genitalia were normal and appeared well-estrogenized. The remainder of the exam was unremarkable. Pelvic ultrasound demonstrated a normal uterus and ovaries. Laboratory evaluation was significant for elevated ...
where Yijk is the kth observation for the ith genotype; µ is the overall mean; Gi is the Genotype effect, Rj is the replication effect while R/Bjk is the effect of blocks nested in replicates, respectively; εijk is the error term associated with Yijk. BLUP variance components estimated...
researcher who believes sugar can provide long term relief for symptoms. It is clearly toxic to the body and deadly in its impact on the function of neural networks. Neurons are the most sensitive cells of the body. If anyone really wants to begin feeling better, one of ...
2A).28 Subsequent molecular modeling studies around this time described the formation of β-hairpins involving the central and C-terminal regions of Aβ, with a turn located around residues 25–28.[29], [30], [31] Although the authors did not explicitly use the term β-hairpin, they ...
This study describes chronic kidney disease of uncertain aetiology (CKDu), which cannot be attributed to diabetes, hypertension or other known aetiologies, that has emerged in the North Central region of Sri Lanka. Methods A cross-sectional study was conducted, to determine the prevalence of and...
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Alzheimer disease (AD) is characterized by progressive cognitive decline in older individuals accompanied by the presence of two pathological protein aggregates — amyloid-β and phosphorylated tau — in the brain. The disease results in brain atrophy caused by neuronal loss and synapse degeneration. ...