For example, the SNP rs2670660 protects against Celiac Disease in the gastrointestinal system; however, this gain-of-function mutation is also associated with the overactivation of the NLRP1 inflammasome in autoimmune disease (Alkhateeb et al., 2013; Jin et al., 2007b; Pontillo et al., 2011,...
Scandinavian journal of gastroenterology. SupplementBrandtzaeg, P. , Valnes, K. , Scott, H. , Rognum, T.O. Bjerke , & Baklien, K. ( 1985 ) The human gastrointestinal secretory immune system in health and disease . Scand. J. Gastroenterol . 20 ( Suppl. 114 ), 17 ....
Eosinophilic Diseases of the Gastrointestinal Tract (GIT) In discussing eosinophilic diseases of the GIT, attention should be drawn to the fact that the GIT forms the largest reservoir of immune and inflammatory cells in the body, a point often forgotten by most basic scientists and clinicians. T...
Inflammatory bowel diseases (IBDs) are chronic immune-mediated diseases of the gastrointestinal tract that are normally classified as Crohn’s disease (CD) or ulcerative colitis (UC) based on histological, imaging, and clinical features1. Despite this classification, a remarkable degree of variability...
Gastrointestinal (GI) dysfunctions, including constipation and delayed stomach emptying, are prevalent and debilitating non-motor symptoms of Parkinson’s disease (PD). These symptoms have been associated with damage in the enteric nervous system (ENS) and the accumulation of pathogenic alpha-synuclein ...
10Stressadverselyaffectstheentirebody,itreducestheabilityoftheimmunesystemtocounteractdisease.Stresscausesseveraldiseasesofthegastrointestinalsystemsuchaspepticulcersandulcerativecolitis.Italsoaggravatesrespiratoryailments—asthma,forexample—andotherallergicconditions.Ifthecauseofadiseaseisnotknown,itissaidtobeidiopathic.11...
Haemangioblastoma is the archetypal vascular neoplasm of the central nervous system (CNS). Cytologically benign, it may occur either as a single lesions or as a multicentric tumour, as a sporadic case or as a familial disease. It constitutes the retinal and neuraxial component of von Hippel-...
Mammalian intestine consists of a stem cell compartment as well as differentiated cells, and its ability to regenerate rapidly after injury makes it an excellent model system to study tissue homeostasis, regeneration and tumorigenesis. Several studies have established the important role of the Hippo ...
Classic Fabry disease is the less common and more severe form of Fabry, characterized by virtually absent (less than 1% of normal) alpha-Gal A activity. Symptoms affecting the nervous system, skin, eyes, and gastrointestinal system usually emerge in childhood or adolescence and eventually progress...
Evolution has endowed the gastrointestinal tract with its own dedicated nervous system. In mammalians, the enteric nervous system (ENS) consists of millions of neurons and glial cells that are organized into interconnected ganglia embedded within the gut wall. The ENS has the ability to autonomously...