Of significance to the debate is that: (1) we have limited information on the real effects of climate, relative to other factors, on the biology of vectors and vector-borne disease, except in a few examples such as Lyme disease (Ogden et al.2004,2005,2006), and on which to base quant...
This is why, currently, almost every country has a set of screening procedures for different communicable diseases of public health significance, in order to avoid the possibility of disease transmission within the population, to detect diseases early, and to treat them promptly. For example, ...
Diverticular disease (DD) is widespread worldwide. The role of gut microbiota (GM) in DD is not entirely understood. Here we discuss the significance of the current knowledge on GM in the different stages of ... Antonio Tursi and Alfredo Papa ...
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, clinically characterised by rest tremors, bradykinesia and shuffling gait, in addition to psychiatric disturbances, cognitive decline and autonomic dysfunction1. One of the main pathological signs of PD is the selective death of dopam...
significance following multiple testing correction.c, Scatterplot of standardized effect sizes (TWASZscores) across adult and fetal brain frontal cortex. A total of 10,722 genes were tested in adult tissue, while 2,293 genes were tested in fetal tissue. The dashed line indicates the expected ...
The significance threshold was set at P = .05. Results Study Population Among 500 total participants (mean [SD] age, 73.0 [8.2] years; 314 men [62.8%] and 186 women [37.2%]), 236 were entered in the 3-way randomization to receive either a dopamine agonist, an MAO-B inhibitor,...
Objectives To describe access to the first biologic DMARD prescription in a population of patients with RA and identical comprehensive health insurance coverage in Ontario, Canada, and to explore the associations of patient, prescriber, and geographic region with differences in time to first biologic ...
Wald tests were used to assess the significance of coefficients in our GEE. To compare marker levels between groups, we modeled markers (calprotectin, dysbiosis, diversity) as a function of disease status (case versus control or UC versus CD). To assess differences between groups at baseline (...
Changes in the levels of circulating proteins are associated with Alzheimer’s disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor of interleukin-33–ST2 signaling, as a new disease-causing factor in AD. Increased circulating...
For b-d, significance was determined by Kruskal-Walis one-way ANOVA with Dunn’s post-hoc test for multiple comparisons. Source data Extended Data Fig. 3 Schematic of the proposed function for each gbu gene cluster encoded enzyme and multiple sequence alignment of acyl-CoA dehydrogenases to Gb...