Two of these mutants exhibit a unique gain-of-function molecular phenotype: A799V exhibits a HCO3−-independent cation leak, while Q913R exhibits a Na+and HCO3−-independent Cl−leak. A homology model of NBCe1, based on the crystal structure of the related protein AE1 (anion exchanger ...
This combined approach is important for long-term adherence and weight maintenance. Several large-scale clinical trials implementing different reduced-calorie dietary patterns have shown that 4 to 10 kg of weight is typically lost. The different hypocaloric dietary patterns s...
We conclude that the term "type 3 diabetes" accurately reflects the fact that AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 diabetes mellitus and T2DM....
Agrawal. Neurofilament Light Chain in Cerebrospinal Fluid as a Novel Biomarker in Evaluating Both Clinical Severity and Therapeutic Response in Niemann-Pick Disease, Type C1. Genet Med. 2022;S1098-3600(22)01037-1.https://doi.org/10.1016/j.gim.2022.11.017,https://pubmed.ncbi.nlm.nih.gov/364...
‘MOVE’ system is saved using the suffix ‘.eeg’, ‘.vhdr’, and ‘.vmrk’, while the filename is random. These three files are generated directly by the ‘MOVE’ system. EEGLab can read them. Raw SC and ACC data are saved using the suffix ‘.csv’. And the filename is the ...
These genes are indicated in our supplementary data by being suffixed with "_X_1", "_X_2" for copy 1, copy 2, etc. Although we report results for 152 separate transcription factors, many regulators dimerize with others to form a protein complex (TF) which has its own specific regula-...
Although they have a short-term symptomatic benefits, their clinical use have revealed important non-cholinergic functions for AChE such its chaperone role in beta-amyloid toxicity. We propose here the design, synthesis and evaluation of non-toxic dual binding site AChEIs by hybrid...
suffix:Jr.ZaidiAkbarA.PetermanThomasA.AIDSAIDSOtten MW, Zaidi AA, Peterman TA, Rolfs RT, Witte JJ. High rate of HIV seroconversion among patients attending urban STD clinics. AIDS 1994; 8: 549-53.Otten MW, Jr, Zaidi AA, Peterman TA, et al. High rate of HIV seroconversion among ...
All attacks are serious and can lead to death or severe long-term consequences.To determine the frequency of specific disease-associated C5 and C6 gene mutations in patients presenting with MD in the Western Cape.In 109 patients with confirmed invasive MD investigated for local ...
Mitchell, D.M