disorder,upset- a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time" hyperparathyroidism- excessive secretion of parathyroid hormone resulting in abnormally high levels of cal...
8c) primarily from the auditory cortex19, was spared from plaque attenuation in ExN-Bace1cKO;AD mice. In fact, immunolabeling of 5×FAD brain slices with the human APP-specific antibody, 1D1, revealed that human APP reactivity in neuronal soma is almost restricted to the cortex (Extended ...
It is often helpful if it can be done safely, to have an audiogram during or immediately following an attack of vertigo. This may show the characteristic low-frequency hearing loss. As the disease progresses hearing loss usually worsens. Other tests such as the auditory brain stem response (...
The editing frequency displayed on heatmap is an average value between three experimental replicates. (B) A-to-G or C-to-other conversion or indel rate after using NG-sg1. The position of base is defined as counting the end distal to the PAM as position 1. (C) Potential sgRNA-...
The middle ear relies in part on fully functioning ciliated epithelial cells and mucus-producing goblet cells for clearance of fluid and debris through the auditory tube. Thus abnormal cilia equates to abnormal auditory tube clearance. Macroscopic lesions include bilateral mucopurulent rhinitis, sinus...
The expression of MITF is regulated by other transcription factors such as cyclic adenosine monophosphate (cAMP) responsive element-binding protein (CREB), paired box gene 3 (PAX3) which is mutated in WS type-1 and − 3 (OMIM#193500/#148820), SOX transcription factors 9 (SOX9) or 10...
Extratelencephalic projection (ET) neurons in the PFC play a key role in short-term working memory, but the mechanism between ET neuronal dysfunction in the PFC and short-term memory impairment in AD is not well understood. Here, using fiber photometry and optogenetics, we found reduced neural...
so that food is chewed with difficulty, while bulbar muscle involvement leads to problems with phonation, articulation, andswallowing. Diseased muscles may also swell and be tender to the touch, or they may cramp. In the condition known asmyotoniathey continue to contract even when the individual...
S2). It is noteworthy that the values acquired when using these models can differ depending on the software or experimental methods used to acquire the physicochemical values and did not use the same software as the models were trained with. In this study, ChemOfficeTM was used for all ...
Pompe disease is a single disease which manifests as a clinical spectrum that varies with respect to age at onset, rate of disease progression, and extent of organ involvement. The advent of en- zyme replacement therapy for this condition will necessitate early diagnosis. This guideline for the...