Possession of a positive charge at physiological pH 7–8 favors brain permeation, so amine-containing compounds with a pK a = 7.5–10.5 are ideal despite the potential for issues with hERG potassium channel binding. Keeping the tPSA < 60–70 Å2, the number of HBD < 3 (CNS drugs have...
Discovery+ launches with “the largest-ever content offering of any new streaming service” according to Discovery, with a back catalogue of unscripted shows from Discovery Channel, HGTV, Food Network, A&E, TLC, Animal Planet, Travel Channel, and History Channel, as well as Discovery+ originals...
Discovery and Zaslav have long been the defenders of the cable bundle, combining the likes of Discovery Channel, TLC, Animal Planet, HGTV, Magnolia Network (f.k.a. DIY Network), Science Channel, Food Network, ID, OWN, Cooking Channel, Trvl Channel, Motortrend, and more into one collection...
Ten years later, and with the data corresponding to the production of a 30-times larger number of Higgs bosons, we have learnt much more about the properties of the Higgs boson. The CMS experiment has observed the Higgs boson in numerous fermionic and bosonic decay channels, established its ...
“We might be seeing a completely different channel for cosmic cataclysms,” she said. The unusual explosions promise to provide new insight into stellar lifecycles typically only seen in snapshots of different stages – star, explosion, remnants – and not as part of a single system, Ho said....
enabling much more precise measurements and new tests of the theory. Here, on the basis of this larger dataset, we combine an unprecedented number of production and decay processes of the Higgs boson to scrutinize its interactions with elementary particles. Interactions with gluons, photons, andWan...
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Zebrafish genome also enables the transfer of genomic information between zebrafish and others species, such as Mexican tetra11, gudgeons42, common carp43, rainbow trout44, and channel catfish45. The syntenic relationships and functional annotation of zebrafish allowed for annotation of the SNPs from...
& Seletsky, B. M. From micrograms to grams: scale-up synthesis of eribulin mesylate. Nat. Prod. Rep. 30, 1158–1164 (2013). CAS PubMed Google Scholar van Kesteren, C. et al. Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin. Anticancer Drugs ...