Choosing a proper strategy is the first step or prerequisite for drug design/discovery, particularly rational design of multitarget drugs (MTDs), which has been discussed in Chap. 18 . And using appropriate web-based data resources for initial analyses and predictions is the next step to success...
Multi-target drugs against selective multiple targets improve therapeutic efficacy, safety and resistance profiles by collective regulations of a primary therapeutic target together with compensatory elements and resistance activities. Efforts have been made to employ in-silico methods for facilitating the sea...
including multi-component, multi-target and multi-pathway9. For example, research indicated that Qili Qiangxin capsules had good effect for CHF and could reduce the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP)10. And some of the TCM herbs and formulas also ...
Popular diabetes and weight-loss drug may reduce risk of Alzheimer's disease Researchers at the Case Western Reserve School of Medicine have found that when compared to seven other anti-diabetic drugs, semaglutide, a popular diabetes and weight-loss drug, may lower the risk of Alzheimer's diseas...
当当中国进口图书旗舰店在线销售正版《预订 Polypharmacology: Strategies for Multi-Target Drug Discovery 应用多重药理学与多靶点药物发现策略: 9781394182831》。最新《预订 Polypharmacology: Strategies for Multi-Target Drug Discovery 应用多重药理学与多靶点药物
Knowledge and investigation of therapeutic targets (responsible for drug efficacy) and the targeted drugs facilitate target and drug discovery and validation. Therapeutic Target Database (TTD, http://bidd.nus.edu.sg/group/ttd/ttd.asp) has been developed to provide comprehensive information about effic...
IRDiRC perspectives on the application of digital biomarkers in therapeutic development for rare diseases New approaches are needed to streamline clinical trials of drugs for patients with rare diseases. Digital biomarkers offer one such approach, but several challenges must be addressed to realize their...
Hundreds of mediators chemically related to the endocannabinoids, often with similar metabolic pathways but different targets, have complicated the development of inhibitors of endocannabinoid metabolic enzymes but have also stimulated the rational design of multi-target drugs. Meanwhile, drugs based on ...
formulation), miltefosine (Impavido™) and paromomycin (Humatin®) are classically used for the treatment of leishmaniasis; however, these drugs present a number of limitations, including high cost, limited efficacy, and disabling side effects due to high toxicity and extended period of treatment...
Indeed, in the years, these concepts have triggered the interest of the drug discovery community both in academia and pharmaceutical companies to such a point that a plethora of multi-target drugs are already available on the market. The analysis of FDA-approved new molecular entities (NMEs) ...