This work set the stage for my subsequent research at Stanford University, where the repair replication of damaged DNA was documented, to provide compelling evidence for an excision-repair pathway. That universal pathway validates the requirement for the redundant information in the c...
[7] Frank, Andreas O., et al. "Discovery of a potent inhibitor of replication protein a protein–protein interactions using a fragment-linking approach." Journal of medicinal chemistry 56.22 (2013): 9242-9250. [8]Hudso...
Whereas discovery of new theories and hypotheses was the subject of extensive philosophical discourse,Footnote4philosophers paid much less attention to the philosophy of discovery of factual entities. Three factors contributed to this asymmetry. First, because philosophy of science of the nineteenth and t...
During the early years of Levene's career, neither Levene nor any other scientist of the time knew how the individual nucleotide components of DNA were arranged in space; discovery of the sugar-phosphate backbone of the DNA molecule was still years away. The large number of molecular groups ma...
Seed size/weight is a major agronomic trait which determine crop productivity in legumes. To understand the genetic basis of seed size determination, we sought to identify DNA polymorphisms between two small (Himchana 1 and Pusa 362) and two large-seeded
of one cycle of growth, replication, and maturation into multiplied invasive parasites. The parasites' chromatin status at all seven time points was analyzed by FAIRE-seq. Briefly, the method involves the chemical cross-linking of the chromatin followed by shearing, protein-free DNA purification, ...
Deposition of chromosomal protein HMG-17 during replication affects the nucleosomal ladder and transcriptional potential of nascent chromatin. A cell-free system from Xenopus eggs was used to study the role of chromosomal protein HMG-17 in the generation of the chromatin structure of transcription......
“DNA-dependent DNA replication initiation”, “regulation of cell cycle”, “DNA unwinding involved in replication”, “cell cycle and microtubule-based movement activity”. The MF categories displaying the highest level of enrichment were “carboxylesterase activity”, “lipid binding”, “microtubule...
5d, e). We focused on downregulated genes (gstA, dadA, yhiI, gorA, and cspD) that have been shown previously to interfere with the cellular states, including inhibition of DNA replication, stress response, drug detoxification, and export57,58,59,60,61,62,63. Given their importance in ...
A. Discovery of daclatasvir, a pan-genotypic hepatitis C virus NS5A replication complex inhibitor with potent clinical effect. J. Med. Chem. 57, 5057–5071 (2014). CAS PubMed Google Scholar Petersen, D. N. et al. A small-molecule anti-secretagogue of PCSK9 targets the 80S ribosome to...