The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis1–9. Deep learning approaches have aided in exploring chemical spaces1,10–15; these typically use black box models and do not
The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis1. Deep learning approaches have aided in exploring chemical spaces; these typically use black box models and do not provide chemical insights. Here we reasoned that the chemic...
The success rate has been extremely low for the identification of novel antibacterial agents by concerted genomic and high-throughput screening initiatives, meaning that a new strategy is now required to develop the next generation of antibiotics. Although structure-based drug discovery is still in its...
-lactamases are the most widespread resistance Several classes of non-lactam inhibitors of -lactamechanisms to -lactam antibiotics, and there is a mases have been identified. Transition-state analog inpressing need for novel, non-lactam drugs. A datahibitors (Figure 1C), such as boronic acids ...
New antibiotics are necessary to treat microbial pathogens that are becoming increasingly resistant to available treatment. Despite the medical need, the number of newly approved drugs continues to decline. We offer an overview of the pipeline for new an
For example, microcin E492 has a minimum inhibitory concentration (MIC)4 of 40 nm against Escherichia coli B (4), whereas microcin J25 has a MIC of 5 nm against S. enterica serotype Newport (5). The potent yet narrow-spectrum activity of microcins make them potential new antibiotics ...
This study identified the AMCs as a novel class of antibiotics evolved from tetracycline that exhibit potent activity in vitro against tetracycline-resistant Gram-positive bacteria, including pathogenic strains of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE). One ...
Further structural and functional analysis of the best hit allowed the identification of a novel class of benzisothiazolinone-based compounds as potent and promising sortase inhibitors. 展开 关键词: Sortase A High-throughput screening Structure-activity relationship Inhibitor ...
and some Enterobacteriaceae has renewed the interest toward narrow-spectrum compounds, to avoid other clinical conditions associated with the use of broad-spectrum antibiotics. However, because of a long history of success in the empirical treatment of infections, many hospitals lack rapid and effective...
class was first identified by its ability to kill bacteria; in some cases, the mode of action was not determined until many years later.5 In contrast, target-based screening strategies to identify inhibitors of essential proteins have been less successful in generating novel antibiotics with ...