• Strategy (Healthcare) • Supply Chain / Manufacturing & Operations (Healthcare & Life Science) • R&D Electronics • Pharmacy Verwirklichen Sie Ihre persönlichen Ziele und entdecken Sie vielfältige Karrieremöglichkeiten! Bewerbungsschluss ist der 20. Oktober 2024. ...
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical ba
Pharmacy Department & Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, P. R. China Shun Shen State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Shanghai Cancer Center, Fudan...
In need of dental care? Ecobiza Dental Clinic is just around the corner, providing a range of dental services to ensure your oral health is in good hands. Additionally, Pharmacy ni Doc is also nearby, offering a convenient option for any medical needs or supplies you may require during ...
Pharmacy Department & Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, P. R. China Shun Shen State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Shanghai Cancer Center, Fudan...
The models described and critically evaluated in this review enable three key aims to be achieved during the drug discovery and development process. Firstly, target engagement is confirmed and modulation correlated with tumour response before validating the target in the preclinical setting, typically in...
Discovery of a potent benzoxaborole- based anti-pneumococcal agent targeting leucyl-tRNA synthetase Qing-Hua Hu1*, Ru-Juan Liu1*, Zhi-Peng Fang1, Jiong Zhang2, Ying-Ying Ding3, Min Tan1, Meng Wang1, Wei Pan3, Hu-Chen Zhou2 & En-Duo Wang1 1State Key Laboratory of Molecular ...
Nodes in the spectral network represent spectra and edges connect “similar” spectra (see “Methods”). Full size image Results Outline of the NRPminer algorithm Figure 1 illustrates the NRPminer algorithm. All NRPminer’s steps are described in detail in the “Methods” section. Briefly, NRP...
RIPK1 is a serine/threonine protein kinase that participates in a variety of signaling pathways involved in cell survival28. In particular, RIPK1 is a key regulator of programmed cell necrosis (necroptosis)28,29, which is closely related to the occurrence and development of various inflammatory an...
Cancer often exhibits abnormal acetylation modifications that can lead to the silencing of key tumor suppressor genes [77]. HDAC inhibitors (HDACis) can block HDAC deacetylase activity. This restores cellular acetylation homeostasis and results in unrestricted HAT activity. This leads to increased gene...