Abnormal regulation of GPCR is associated with various human diseases, such as metabolic diseases, cardiovascular diseases, and eye diseases. G protein contains three subunits: α, β, and γ, which form a trimer. When extracellular ligands are bound to GPCRs which activate G protein and GTP ...
et al. Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells. PLoS ONE 13, e0189247 (2018). PubMed PubMed Central Google Scholar Subramanian, A. et al. A next generation Connectivity ...
mRNA vaccines represent a promising alternative to conventional vaccine approaches, but their application has been hampered by instability and delivery issues. Here, Pardi and colleagues discuss recent advances in mRNA vaccine technology, assess mRNA vac
the nanotechnology application size limit. To circumvent the ambiguity of the terms microplastic and nanoplastic particles in this article we will refer to ‘plastic particles’ and where appropriate define the size or size range. Our study was concerned with plastic particles that can be absorbed ...
The pioneering quantum physicist Paul Dirac commented in 1929 that“The underlying physical laws necessary for the mathematical theory of a large part of physics and the whole of chemistry are thus completely known, and the difficulty is only that the exact application of these laws leads to equat...
The pioneering quantum physicist Paul Dirac commented in 1929 that“The underlying physical laws necessary for the mathematical theory of a large part of physics and the whole of chemistry are thus completely known, and the difficulty is only that the exact application of these laws leads to equat...
//zenodo.org/records/13381201.cApplication of mechanistic transforms to a given set of starting materials iteratively expands the synthetic generations,Gn, of a network of possible intermediates and immediate by-products. In the schematic miniature drawn, the three circle markers in the bottom row (...
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and reduced retinal thickening after VEGF injection by 37% (p = 0.0018) and 59% (p = 0.008), respectively [80]. PKa inhibition by VA999272 also reduced retinal thickening (57%, p < 0.001) induced by VEGF application [81]. The effect was comparable to that in KLKB1-...