Chemical scaffolds of drugs that are active against parasites in vitro and in a mouse model of HAT could be subsequently optimized through medicinal chemistry efforts to create novel anti-trypanosome compounds10,11. Carbazole scaffolds are found in some marketed drugs or are "hits" in development ...
Theo is, on the one hand, thrust into adulthood by his loss, and on the other still very much a child, as he comes of age in the wake of the attack and struggles with his arrested development. Packed full of unrequited love, drugs, and art theft, despite being almost 800 pages long...
The most promising PD13 displayed strong inhibitory activity against wild-type (IC50 of 11.64 ± 1.30 nM), L858R/T790M (IC50 of 10.51 ± 0.71 nM), which are more significant than known drugs. In addition, PD13 revealed a potent cytotoxic effect on A549 and H1975 cell lines with IC50 ...