CRBN resistance mutations were used to show that thalidomide binding to CRBN was necessary for thalidomide’s teratogenicity in zebrafish. Article CAS PubMed Google Scholar Wu, T. et al. Targeted protein degradation as a powerful research tool in basic biology and drug target discovery. Nat. ...
Molecules that covalently engage target proteins are widely used as activity-based probes and covalent drugs. The performance of these covalent inhibitors is, however, often compromised by the paradox of efficacy and risk, which demands a balance between reactivity and selectivity. The challenge is mo...
We used the online tool ToppGene for GO enrichment analysis, which identified the most significant terms in the MF, BP, and CC categories were cytokine activity, inflammatory response, and external side of plasma membrane, respectively. This was consistent with our hypothesis. For the enrichment pa...
The enzyme is used in an assay for inhibitors of the synthetase and can be used as an antigen for producing antibody inhibitors of the disease, either mo... MA Kron,R Leberman 被引量: 40发表: 1996年 Brugia malayi Asparaginyl-Transfer RNA Synthetase Induces Chemotaxis of Human Leukocytes ...
A dominant learning style is just one learning style used for all educational purposes and understanding new concepts. Still, your dominant learning style won’t be the only one you use. Learning styles aren’t static so you can develop the ones you use or you can start using new ones. Th...
Each chapter starts by providing a useful inventory of definitions and commonly used acronyms for each topic and throughout the text, the reader finds several real-world examples, methodologies and ideas that complement the technical and theoretical background. This new edition includes new sections ...
Fig. 2.. Comparison of the antibiotic MOA prediction accuracy for different experimental settings used for the mRNA training profiles. As a measure of the MOA classification accuracy, the average MCR has been calculated using an SVM classification approach in conjunction with a leave-X-out strategy...
- Arteriosclerosis, Thrombosis, and Vascular Biology 被引量: 0发表: 2024年 Uncover: Toward Interpretable Models for Detecting New Star Cluster Members In this design study, we present Uncover, an interactive tool aimed at astronomers to find previously unidentified member stars in stellar clusters. ...
For hundreds of years humans have dreamed of finding life on distant planets.Now the hope of discovering real evidence of life has greatly increased. NASA's Mars detector,Opportunity,succeeded in finding signs that water once existed on the planet.Opport
With the goal of leveraging the potential of the methods in capturing signals for regions under selection, we combined three complementary statistics with specific programs that can be used to calculate them62: Runs Of Homozygosity (ROH), FST-outliers detection and HapFLK methods were applied. ROH...