ability to reliably predict functions from gene sequences alone using ML will allow robust exploration of molecular-evolutionary patterns governing phenotype, will inform functional and evolutionary connections to an organism's ecological niche, and may be used more broadly for de novo protein design. ...
CRBN resistance mutations were used to show that thalidomide binding to CRBN was necessary for thalidomide’s teratogenicity in zebrafish. Article CAS PubMed Google Scholar Wu, T. et al. Targeted protein degradation as a powerful research tool in basic biology and drug target discovery. Nat. ...
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With its availability as AI/ML input, it can be used directly for predictive analysis2,34,35. To address this challenge, we propose the Clinically Integrated Genomics and Transcriptomics (CIGT) format, which integrates heterogeneous clinical, demographic, genomic and transcriptomic patient data. Due ...
substrate [147]. These X-ray crystal structures reveal SIRT5 acyl selectivity and its molecular basis, which enable the design of SIRT5 inhibitors. Specifically, rapid overlay of chemical structures (ROCS), ShaEP, and Phase Shape can be used to identify small-molecule compounds with similar ...
Design and validation of graph neural network models We next used our screening data to train deep learning models that predict senolytic activity on the basis of chemical structure. Building on our work in antibiotic discovery23, we employed message-passing graph neural network models...
From the generated N binary decision support, a stability selection procedure is used to retain associations with stability path \(\Pi \ge \pi _\text {thr}\). Full size image Multi-view dataset This study uses the Healthy Brain Network (HBN) cohort38. This dataset is a multi-centre, ...
The notation of support is widely used in associa- tion rule mining [4]. One motif is said to be frequent if its support is no less than a given threshold. The aim of introducing support constraint is two-fold: on the one hand, it can filter out non-frequent motifs that may cor- ...
• SW1PerS can be used on data with low temporal resolution and uneven time spacing. • While the algorithm requires the selection of certain parameters (e.g. window size, embedding dimension, etc), the theory behind the method suggests reasonable values. • Even though the inner-...
The ‘essence’, of collaborative leadership in the definition we used with the group lies in the interaction, the “behaving together”. Step Two: use video as stimulus to illustrate these new ideas Despite the groups’ expressed interest in exploring these new conceptualizations of leadership, ...