The reduced cytotoxic activity of the MMAF derivative compared to MMAE is attributed to MMAF's C-terminal phenylalanine residue, which carries a charge that interferes with intracellular pathways. To address this, MMAF-OMe (10) replaces the hydroxyl group of MMAF's C-terminal phenylalanine residue...
To date, approximately 100 DUB species have been identified in humans, divided into seven subfamilies: ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), ovarian tumor proteases (OTUs), Machado-Joseph disease protein proteases (MJDs), Jab1/Mov34/MPN+ proteases (JAMMs),...
In general, radiation therapy is not the primary treatment strategy for leukemia. However, combining HDAC inhibitors with radiation therapy has the potential to enhance the efficacy of palliative radiotherapy and overcome tumor resistance mechanisms in the treatment of leukemia metastases. The rationale be...
There are multiple anti-HER2 therapies currently approved by the FDA, many of which have emerged within the last 2 years. It is becoming increasingly difficult for clinicians in busy practices to decide on which particular anti-HER2 therapy to use, especially in the late-line treatment of metast...
Regardless, it has been suggested that viruses whose hosts are in closer association with bacteria tend to encode more putative non-ancestral genes, and that these genes cluster near the terminal ends of the viral genome [107]. However, while the Chlorella algae is an endosymbiont of Paramecium...
Some manufacturers like Wolfspeed have also been including an additional Kelvin source terminal with their discrete devices as well. SiC power devices have the potential to impact power density at all levels in the package—a reduction in the size and number of power devices, a reduction in the...