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Opioid modulation with buprenorphine/samidorphan as adjunctive treatment for inadequate response to antidepressants: a randomized double-blind placebo-controlled trial. Am J Psychiatry 2016; 173: 499–508. Article PubMed Google Scholar Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, ...
The emergence of antibody-drug conjugates (ADCs) as a potential therapeutic avenue in cancer treatment has garnered significant attention. By combining the selective specificity of monoclonal antibodies with the cytotoxicity of drug molecules, ADCs aim to increase the therapeutic index, selectively targeti...
T1-W DCEis sensitive to the presence of CA in the extravascular extracellular space. Tofts’ standard pharmacokinetic model is the mathematical model most commonly used in clinical studies for analyzing human DCE-MRI data.118Tofts’ model introduces three key parameters, namely,Ktrans,Ve, andVp.119...
The aim of the present review is to discuss how the promising field of biobanking can support health care research strategies. As the concept has evolved over time, biobanks have grown from simple biological sample repositories to complex and dynamic uni
T2*-W DCEis sensitive to the vascular phase of CA and is used to evaluate tissue perfusion and blood volume. The following parameters are measured inT2*-W DCE: (1) regional blood volume (rBV), which is defined as the volume (ml) of blood perfusing vessels in a voxel divided by the...
Among these conjugates, cytotoxic molecules of natural origin are summarized based on their mechanism of action, conformational relationships, and the discovery of new derivatives. This paper also mentions some cytotoxic molecules that have the potential to be payloads. It also summarizes the latest ...
Driver genes and sorafenib resistance in HCC High-throughput genome-wide screening tools have been employed for the identification of driver genes responsible for the drug resistant phenotype of cancer cells, leading to the discovery of new targets and possible treatment com binations. In a ...
Significantly, the VCA region of WAVE proteins interacts with two different protein types to start actin polymerization. The CA domain interacts with the Arp2/3 complex, while the V domain binds to actin monomers (G-actin). This dual binding allows actin monomers be more closely associated with...
Complex and multifactorial, the oncogenesis process involves genetic alteration, epigenetic modification, and a dysregulated tumor microenvironment. Although various therapeutic interventions, such as chemotherapy, radiation, immunotherapy, and nanomedicine, have been proposed to prevent or treat OSCC and OP...