More recently, impaired leukocyte function has been implicated as an additional factor in the pathophysiology of radiation injury. Reconstructive surgical plans may require alteration when operating in a radiated field, especially in the head and neck. Radiation wounds are best treated by standard, ...
Frostbite is a severe form of localized cold-induced tissue injury that occurs when skin or deeper tissue temperature falls below − 2 °C, at which point ice crystals form at the cellular level, resulting in cellular dysfunction or destruction and, during rewarming, microvascular occlusion (Jur...
Radiation-induced lung injury (RILI) variously occurs (1%-50%) after AWBRT according to different series (prospective or retrospective) and to the heterogeneity of the scoring systems and clinical endpoints employed[12]. If clinically significant radiation pneumonitis (RP) is considered, it may be...
Both primary and metastatic malignant brain tumors are treated with total surgical resection of the bulk tumor mass followed by a combination of chemotherapy and radiation therapy4,5,6. Brain metastatic tumors account for the majority of malignant brain tumors, and for patients with breast cancer ...
This finding expands the growing list of targets for which CsrA-binding occurs through a combination of a high-affinity GGA site and a degenerate, non-consensus ANGGN motif, as previously reported [4,9]. While the use of degenerate binding sites might be a more prevalent phenomenon among ...
The high absorption rate of the samples for the spectrum from the visible to near-infrared will help thermal storage in the DASC under solar radiation. Figure 3. Actual photos of the carbon-based nanofluids after standing for 30 days. Figure 4. Absorption rate spectrum of the samples. The...
drugs were given in combination, the dose was reduced due to toxicity, which is often the case in actual practice. If full doses of all agents can be given simultaneously, simultaneous combinations are optimal [42], but when that is not the case a more complex strategic dilemma occurs. ...
When a tissue is injured, a sequence of events leads to the repair of the injured tissue. Tissue repair (wound repair) occurs in three overlapping phases, the inflammatory, proliferative, and remodeling phases[1]. In the inflammatory phase, leukocytes, such as neutrophils, lymphocytes, and monoc...
Radiation injury is a continuum of complex biological responses. At the time of emergency, multiple methods of technologies are used to monitor radiation exposure levels and measure cellular damage. Identifying markers of exposure and finding unique biomarker profiles for toxicity in exposed individuals ...
Typical precipitating events are trauma (frequently iatrogenic), infection, inflammation, tumours, metabolic abnormalities, malnutrition, ischaemia, vascular abnormalities, neurotoxins (including chemotherapeutic agents), radiation, inherited mutations and autoimmune attack. If damage occurs suddenly ‘injury ...