Most patients have mutations (autosomal recessive type of inheritance) of the autoimmune regulator gene on chromosome 21. About 18% of patients with APS-1 develop T1D. Patients with the common diabetes-protective HLA allele DQB*10602 have some protection from T1D; however, it does not prevent...
Mode of Inheritance and Prevalence Best estimates of prevalence are of 1 in 100,000 male births.4An X-linked recessive, the disorder occurs almost exclusively in males. Age of Onset and Disease Evolution The disease may express as uricosuria in early infancy. In the classic disease, which acc...