Raised indirect bilirubin level. Severity of disease is predicted by: • history indicating the severity of hemolytic disease of the newborn in previous infants; • the type of RBC antigen mismatch (e.g., hemolytic disease due to Rh mismatch is generally more severe than ABO mis...
In unconjugated hyperbilirubinemia, the total serum bilirubin is raised with less than 15% bilirubin reported to be in the direct reacting form. It may be physiological in the newborn. It is frequently caused because of hematological causes. The genetic or familial functional disorders considered in...
Concern has also been raised that unregulated complement activation can occur in selected infants who undergo extracorporeal membrane oxygenation therapy (Johnson, 1994; Kozik and Tweddell, 2006). Complement activation is an important regulator of multiple functions of the host immunologic response. ...
In 21 patients, the raised direct bilirubin concentration returned to normal while they continued to receive parenteral nutrition. Seven patients progressed to liver failure. Patients without cholestasis had been dependent on parenteral nutrition for longer than patients with cholestasis. It was clear ...
21What are the physiologic causes of hyperbilirubinemia in newborns? • Neonatal jaundiceis caused mainly by changes inbilirubin metabolismthat result in increased bilirubin production. • The newborn infant produces two to three times higher bilirubin than do adults. This is due to increased numbe...
The realization that fully 60% of drugs listed in the Physicians Desk Reference have positive CHC chromosome aberration findings associated with them has raised concerns about this assay. The CHO cells used in this assay may be obtained from the American Tissue Culture Collection, Rockville, ...
Jaundice is a clinical sign and is not observed until the bilirubin concentration in plasma exceeds about 40μmol/L (2.3mg/dL). Literally, the patient appears yellow (obvious in thesclera, skin, and mucous membranes). The most common molecular cause of jaundice is a raised bilirubin concentrat...
Bilirubin is a yellow pigment, which explains why hyperbilirubinemia, if severe enough, causes icterus—the grossly visible yellowing of fluid or tissues (Fig. 13-10). Icterus, also known as jaundice, is usually detectable when the plasma bilirubin concentration exceeds 2 mg/dL. However, it ...
(case fatality rate, 55%).67,68In addition to fever, hypotension, and respiratory failure, these people had markedly elevated hepatocellular enzymes and bilirubin,lymphocytopenia, and thrombocytopenia. Vaccine-typeyellow fever viruswas isolated from the blood of two people on the seventh and eighth ...
Reports document the interaction of three diuretics with bilirubin-albumin complexes.185 Chlorothiazide presented the greatest risk for producing free bilirubin, with ethacrynic acid and furosemide producing considerably less. The latter two are clinically effective in lower doses as well. The levels of...