PROBLEM TO BE SOLVED: To provide new DPP-IV (dipeptidyl peptidase-IV) inhibitors having favorable titer, stability, selectivity, toxicity and/or pharmacological properties.ジュン フェンスティーブン エル グウォルトニー ザ セカンドスティーブン ダブリュ カルダージェフリー エイ スタフォ...
Dipeptidyl peptidase-4 (DPP-4) inhibitors constitute a novel class of anti-diabetic agents confirmed to improve glycemic control and preserve β-cell function in type 2 diabetes. Three major large-scale studies, EXAMINE, SAVOR-TIMI 53, and TECOS, have confirmed the cardiovascular safety profile o...
必应词典为您提供dipeptidyl-peptidase-iv-inhibitors的释义,网络释义: 抑制剂;二肽基肽酶;
without inducing hypoglycaemia or weight gain, in patients with T2DM. Dipeptidylpeptidase-4 (DPP-4) inhibitors are novel oral glucose-lowering agents, which may be used as monotherapy or in combination with other antidiabetic compounds, metformin, thiazolidinediones or even sulfonylureas. Sitagliptin...
二肽基肽酶-4(Dipeptidyl peptidase-4,DPP-4)抑制剂是一种新型降糖药物,主要通过抑制内源性肠促胰岛素-胰高血糖素样肽-1和葡萄糖依赖性促胰岛素多肽的降解而起到降血糖的作用。许多研究已证实DPP-4抑制剂对2型糖尿病患者的胰岛β细胞具有保护作用。DPP-4是一种在体内广泛表达的酶,由此推测DPP-4抑制剂是一种多...
2) Dipeptidyl peptidase IV inhibitors 二肽基肽酶Ⅳ抑制剂 1. Dipeptidyl peptidase IV inhibitors as the new treatment for this disease appears to be more promising. 二肽基肽酶Ⅳ抑制剂作为新型抗糖尿病药物越来越引起人们关注。 更多例句>> 3) Dipeptidyl peptidase-Ⅳ inhibitors 二肽酶-Ⅳ抑制剂...
The physician has now multiple choices to manage his/her patient after secondary failure of metformin, and the question whether it is preferable to add an oral dipeptidylpeptidase-4 (DPP-4) inhibitor (gliptin) or an injectable glucagon-like peptide-1 (GLP-1) receptor agonist will emerge. ...
Dipeptidyl peptidase (DPP-IV) inhibitors suppress the degradation of many peptides, including GLP-1, thereby extending their bioactivity. 二肽酶(民进党四)抑制剂抑制多肽降解,包括血糖素样肽1,从而延长它们的生物活性。 www.syyxw.com 2. LAF237, a dipeptidyl peptidase IV (DPP IV) inhibitor, represen...
The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental...
Systematic low-grade inflammation is considered to be an important factor leading to the development of T2DM and the progression of its complications. Dipeptidyl-peptidase-4 (DPP-4) inhibitors show potential anti-inflammatory effects in patients with T2DM. This meta-analysis aimed to evaluate the ant...