The dipeptidyl peptidase-4 inhibitors (DPP-4is) are oral, weight-neutral hypoglycemic drugs used to treat patients with T2DM by preventing the breakdown of glucagon-like peptide-1 and glucose-dependent insulinotropic peptide, two incretins pivotal for glucose regulation. This short chapter will ...
Dipeptidyl peptidase-4 (DPP-4) inhibitors constitute a novel class of anti-diabetic agents confirmed to improve glycemic control and preserve β-cell function in type 2 diabetes. Three major large-scale studies, EXAMINE, SAVOR-TIMI 53, and TECOS, have confirmed the cardiovascular safety profile o...
Dipeptidyl peptidase IV (DPP-4) is well known for its role in glucose homeostasis, and DPP-4 inhibitor (DPP-4i) exhibits multiple actions聽in cardiovascular diseases. However, the effect of DPP-4i on pulmonary hypertension (PH) remains unclear. Therefore, this study aims to investigate the ...
The physician has now multiple choices to manage his/her patient after secondary failure of metformin, and the question whether it is preferable to add an oral dipeptidylpeptidase-4 (DPP-4) inhibitor (gliptin) or an injectable glucagon-like peptide-1 (GLP-1) receptor agonist will emerge. ...
Dipeptidyl peptidase 4 inhibitors (DPP4-i)HbA1cType II diabetes mellitus (T2DM)Southeast AsiaIn Malaysia, for more than a decade, dipeptidyl peptidase-4 inhibitors (DPP-4i) are among the oral antidiabetic medications used as monotherapy or in combination to manage type II diabetes mellitus (T2DM...
Effect of Sitagliptin" a Dipeptidyl Peptidase-4 (DPP-4), Inhibitor" on the Endocrine Part of the Pancreas in Experimentally induced ’’Diabetes in Adult Albino Rat; A Light Microscopic and Biochemical Studies. Tamer MM Abu-Amara,Zeinab M. Gebaly. Egyptian Journal of Hospital Medicine . 2012...
The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental...
Dipeptidyl peptidase IV inhibitors Dipeptidyl peptidase IV(DPP IV) is an enzyme that is involved in the rapid metabolism ofincretins, such as glucagon-like peptide. Inhibitors of DPP IV therefore extend the action of incretins. The incretins increase glucose-dependent insulin secretion from the pan...
二肽基肽酶-4(Dipeptidyl peptidase-4,DPP-4)抑制剂是一种新型降糖药物,主要通过抑制内源性肠促胰岛素-胰高血糖素样肽-1和葡萄糖依赖性促胰岛素多肽的降解而起到降血糖的作用。许多研究已证实DPP-4抑制剂对2型糖尿病患者的胰岛β细胞具有保护作用。DPP-4是一种在体内广泛表达的酶,由此推测DPP-4抑制剂是一种多...
New compounds have been developed to improve glucose-induced gB-cell secretion and glucose control, without inducing hypoglycaemia or weight gain, in patients with T2DM. Dipeptidylpeptidase-4 (DPP-4) inhibitors are novel oral glucose-lowering agents, which may be used as monotherapy or in combinatio...